Abciximab

It is used during a heart treatment to protect the arteries. It is used to lower the number of heart attacks in patients who have unstable angina or mild heart attacks.

It is used during a heart treatment to protect the arteries. It is used to lower the number of heart attacks in patients who have unstable angina or mild heart attacks.

Abciximab is contraindicated in conditions like Thrombocytopenia, Cerebrovascular accident, Hypersensitivity, GI bleeding, Vasculitis, Bleeding diathesis, Intracranial neoplasm, Active internal bleeding, Severe uncontrolled hypertension.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash ; hives; itching ; red, swollen, blistered, or peeling skin with or without fever ; wheezing ; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop. Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight. Very bad headache . Very bad dizziness or passing out. Chest pain or pressure. Feeling very tired or weak.

Abciximab should be used with caution in patients with pre-existing illnesses, allergy, recent surgery or trauma. It should not be used if there is any bleeding (e.g. gastrointestinal bleeding) or history of stroke. Abciximab should be used carefully in patients weighing less than 75 Kg or older than 65 years or have a history of gastrointestinal disease. Use with caution during pregnancy and lactation.

Drug should not be given to Pediatrics, Pregnant Mothers, Geriatrics, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

0.25 ug/kg/min (0.25 (0.25)) 24 hourly IV Inf — Maintenance, for 12 hours 0.5 mg/kg (0.5 (0.5)) 24 hourly Slow IV — Initial, bolus over 10-60 min.

( ) — Not recommended in this age group

( ) — Not recommended in this age group

Abciximab is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementHeparin (Na) and Heparin (Cl)ReteplaseConcurrent use may increase the risk of bleeding.TenecteplaseConcurrent use is usually not recommended but may be required in some cases. If both medicines are prescribed together, change of dose may be required.Tirofiban HClTrastuzumab These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Inj Store in refrigerator. Do not Freeze.