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Medicines/Generics/Abiraterone acetate

Abiraterone acetate

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview
Abiraterone works by reducing androgen production in the body. Androgens are male hormones that can promote tumor growth in the prostate gland. Abiraterone is used together with steroid medication ( prednisone or methylprednisolone ) to treat prostate cancer that has spread to other parts of the body. abiraterone is used in men whose prostate cancer cannot be treated with surgery or other medicines. It is not known if abiraterone acetate tablets are safe or effective in females or children.
Indications
Abiraterone works by reducing androgen production in the body. Androgens are male hormones that can promote tumor growth in the prostate gland. Abiraterone is used together with steroid medication ( prednisone or methylprednisolone ) to treat prostate cancer that has spread to other parts of the body. abiraterone is used in men whose prostate cancer cannot be treated with surgery or other medicines. It is not known if abiraterone acetate tablets are safe or effective in females or children.
Contraindications
Abiraterone is not for use by women or children. To make sure this medicine is safe for you, tell your doctor if you have ever had: liver disease; diabetes (especially if you use pioglitazone or repaglinide ); heart problems, high blood pressure ; a heart attack ; low levels of potassium in your blood; or problems with your adrenal gland or pituitary gland. Abiraterone can harm an unborn baby if a woman is exposed to it during pregnancy. An abiraterone tablet should not be handled by a woman who is pregnant or may become pregnant. The medicine from a broken tablet could be absorbed through the skin. Abiraterone can also harm an unborn baby if the father is taking this medicine at the time of conception or during pregnancy. Use effective birth control if your sex partner is pregnant or able to get pregnant. Keep using birth control for at least 3 weeks after your last dose.
Side Effects
Get emergency medical help if you have signs of an allergic reaction to abiraterone : hives ; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: swelling in your ankles or feet, pain in your legs; fast or irregular heartbeats; a light-headed feeling, like you might pass out; severe headache , blurred vision, pounding in your neck or ears; pain or burning when you urinate; low red blood cells (anemia) - pale skin, tiredness, feeling light-headed or short of breath, cold hands and feet; low blood potassium - leg cramps, constipation , irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; liver problems - stomach pain (upper right side), nausea , vomiting , dark urine, jaundice (yellowing of the skin or eyes); or low blood sugar - headache, hunger, sweating, irritability, dizziness , fast heart rate , and feeling anxious or shaky. Common abiraterone side effects may include: feeling very weak or tired; feeling very hot; high blood sugar; increased blood pressure; swelling in your legs or feet; anemia, low blood potassium; painful urination; abnormal liver function tests or other blood tests; joint pain or swelling; headache; nausea, vomiting, diarrhea ; or cold symptoms such as stuffy nose, sneezing, cough, sore throat . This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
Abiraterone tablets should not be handled by a woman who is pregnant or who may become pregnant. This medicine can harm an unborn baby or cause miscarriage.
High Risk Groups
Abiraterone tablets should not be handled by a woman who is pregnant or who may become pregnant. This medicine can harm an unborn baby or cause miscarriage.
Adult Dosage
1000 to 1000 mg (1000 (1000)) 24 hourly PO — Must not be taken with food. Taken with 10 mg prednisolone. Scraped Dose — Take abiraterone exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Abiraterone is usually taken once per day while also taking a steroid 1 or 2 times per day. Follow your doctor's dosing instructions very carefully. Your abiraterone dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the medicine your doctor prescribes. Your prednisone or methylprednisolone dose needs may change if you have an infection or are under stress . Do not change your dose or stop using your steroid medicine without your doctor's advice. Take this medicine with a full glass of water. You may take Yonsa with or without food. Take Zytiga on an empty stomach. Do not eat anything for at least 2 hours before and 1 hour after you take Zytiga. Swallow the tablet whole and do not crush, chew, or break it. Your blood pressure will need to be checked often, and you may need frequent blood tests. If you have diabetes, your blood sugar should be checked carefully, especially if you take pioglitazone or repaglinide. You should not stop using abiraterone or your steroid medicine suddenly. Follow your doctor's instructions about tapering your prednisone dose. Store at room temperature away from moisture and heat.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Tell your doctor about all your current medicines. Many drugs can interact with abiraterone, especially: other prostate cancer medicines, especially radium Ra 223 (may increase your risk of fractures while you are taking abiraterone); or pioglitazone or repaglinide to treat diabetes (may cause severe low blood sugar hypoglycemia while you are taking abiraterone. This list is not complete and many other drugs may affect abiraterone. This includes prescription and over-the-counter medicines, vitamins , and herbal products . Not all possible drug interactions are listed here.
Storage
No storage information is recorded for this medicine yet.