Acamprosate Calcium
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Acamprosate calcium is a prescription medication that helps people who are dependent on alcohol to abstain from drinking it. It is used along with psychosocial support and helps to prevent the cravings and urge to drink alcohol that people with alcohol use disorder experience.
Drinking alcohol alters the balance of the chemical messengers or neurotransmitters in your brain. Acamprosate is thought to work by helping to restore the balance of these neurotransmitters. It's thought that it primarily works by decreasing the excessive excitation that accompanies alcohol dependence.
Acamprosate is similar in structure - an analog of - two neurotransmitters called GABA (gamma-aminobutyric acid) and taurine. And while it's not clear exactly how it works, it's been suggested that acamprosate works by targeting GABA and NMDA (N-methyl-D-aspartate) glutamatergic receptor activity. It's also been suggested that it works by supplying calcium.
In 2004, the US Food and Drug Administration (FDA) approved a branded version of acamprosate calcium called Campral. Campral has since been discontinued, but generic versions of acamprosate calcium delayed-release tablets are available.
Indications
Acamprosate calcium is a prescription medication that helps people who are dependent on alcohol to abstain from drinking it. It is used along with psychosocial support and helps to prevent the cravings and urge to drink alcohol that people with alcohol use disorder experience.
Drinking alcohol alters the balance of the chemical messengers or neurotransmitters in your brain. Acamprosate is thought to work by helping to restore the balance of these neurotransmitters. It's thought that it primarily works by decreasing the excessive excitation that accompanies alcohol dependence.
Acamprosate is similar in structure - an analog of - two neurotransmitters called GABA (gamma-aminobutyric acid) and taurine. And while it's not clear exactly how it works, it's been suggested that acamprosate works by targeting GABA and NMDA (N-methyl-D-aspartate) glutamatergic receptor activity. It's also been suggested that it works by supplying calcium.
In 2004, the US Food and Drug Administration (FDA) approved a branded version of acamprosate calcium called Campral. Campral has since been discontinued, but generic versions of acamprosate calcium delayed-release tablets are available.
Contraindications
Do not take acamprosate if you are allergic to acamprosate calcium or any of the other ingredients in it. Do not use acamprosate if you have severe renal impairment.
Side Effects
Common side effects of acamprosate include:
accidental injury asthenia pain anorexia diarrhea flatulence nausea anxiety depression dizziness dry mouth insomnia paresthesia pruritus sweating
These are not all of the possible side effects of acamprosate.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Warnings
Before starting treatment with acamprosate you must have stopped drinking alcohol. If you relapse and start drinking alcohol, continue to take acamprosate and see your healthcare provider as soon as possible. In the event of a relapse, treatment with acamprosate should be continued. Do not stop taking acamprosate, even when you feel better. Talk with your healthcare provider about how long you should take acamprosate for. Missing doses of acamprosate may increase your chances of relapsing. If you have kidney problems you may need lower doses and need blood tests while using acamprosate. If you have severe kidney problems acamprosate may not be right for you. People with substance use disorders are at a higher risk for depression and suicidal thoughts. If you experience any thoughts of self-harm, call 911 or go to your closest emergency room. Acamprosate should be used in combination with counseling and other support.
High Risk Groups
Before starting treatment with acamprosate you must have stopped drinking alcohol. If you relapse and start drinking alcohol, continue to take acamprosate and see your healthcare provider as soon as possible. In the event of a relapse, treatment with acamprosate should be continued. Do not stop taking acamprosate, even when you feel better. Talk with your healthcare provider about how long you should take acamprosate for. Missing doses of acamprosate may increase your chances of relapsing. If you have kidney problems you may need lower doses and need blood tests while using acamprosate. If you have severe kidney problems acamprosate may not be right for you. People with substance use disorders are at a higher risk for depression and suicidal thoughts. If you experience any thoughts of self-harm, call 911 or go to your closest emergency room. Acamprosate should be used in combination with counseling and other support.
Adult Dosage
333 mg thrice day (330 (333)) As recommended. PO — This dose is for patients with renal impaired function.
666 mg thrice day (670 (666)) As recommended. PO — 666 mg means two 333mg tablets should be taken thrice a day.
Scraped Dose — Take acamprosate exactly as your doctor tells you to. Take two tablets three times a day or as directed by your doctor. Acamprosate can be taken with or without food. Swallow tablets whole. Do not crush or chew.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Storage
Tablet Store at room temperature.
Available Brands in Pakistan
No brands are recorded for this generic.
