Alprostadil
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Alprostadil is used to treat erectile dysfunction ( impotence ) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with heart problems. This medication guide addresses only the adult male use of alprostadil in erectile disorders.
Alprostadil relaxes blood vessels and muscles in the penis which increases blood flow, causing an erection.
Alprostadil may also be used for purposes not listed in this medication guide.
Indications
Alprostadil is used to treat erectile dysfunction ( impotence ) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with heart problems. This medication guide addresses only the adult male use of alprostadil in erectile disorders.
Alprostadil relaxes blood vessels and muscles in the penis which increases blood flow, causing an erection.
Alprostadil may also be used for purposes not listed in this medication guide.
Contraindications
You should not use alprostadil if you are allergic to it, or if you have:
sickle cell anemia or the sickle cell trait; leukemia ; a tumor of the bone marrow ( multiple myeloma ); a curved or deformed penis; penile fibrosis or Peyronie's disease ; if you have a penile implant; or if you must avoid sexual intercourse for health reasons.
Tell your doctor if you have ever had:
heart disease ; high or low blood pressure ; or bleeding problems.
Caverject, Caverject Impulse, Edex, or Muse should not be used by women or by anyone under 18 years old.
While using alprostadil pellets, use condoms during sex if your partner is pregnant or able to get pregnant. The effects of alprostadil on an unborn baby at conception or during pregnancy are unknown.
Side Effects
Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Alprostadil may cause serious side effects. Stop using alprostadil and call your doctor at once if you have:
a light-headed feeling, like you might pass out; bleeding after an injection; a painful erection that lasts 4 hours or longer; new or worsening pain in your penis; or redness, swelling, tenderness, lumps, unusual shape or curving of the erect penis.
Common side effects of alprostadil may include:
mild pain in your penis, urethra, or testicles; redness of the penis; or warmth or burning in your urethra.
Your sex partner may have side effects such as burning, itching , or irritation of body areas that come into contact with your penis.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
This medication guide addresses only the adult male use of alprostadil in erectile disorders.
Seek emergency medical attention if you have a painful or prolonged erection lasting 4 hours or longer.
High Risk Groups
This medication guide addresses only the adult male use of alprostadil in erectile disorders.
Seek emergency medical attention if you have a painful or prolonged erection lasting 4 hours or longer.
Adult Dosage
50 to 100 ng/ kg/min (75 (75)) As recommended. IV-inf — Initial dose. Advance to 0.2 mcg/kg/min if necessary. USUALLY GIVEN TO NEONATES. For Maintenance dose; When increase in PaO2 is noted, decrease immediately to lowest effective dose.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
5 to 100 ng/kg/min (52 (52.5)) As recommended. IV-inf — Initially 5 ng/kg/min adjust according to responce in steps of 5ng/kg/min
Drug Interactions
Tell your doctor about all your other medicines, especially:
other medicines injected into the penis; or a blood thinner -- heparin , warfarin , Coumadin , Jantoven .
This list is not complete. Other drugs may affect alprostadil, including prescription and over-the-counter medicines, vitamins , and herbal products . Not all possible drug interactions are listed here.
Storage
Inj Store Below 25°C. Protect from Sunlight. Suppositories Store in refrigerator.
Available Brands in Pakistan
1 active brand listed alphabetically.
PROSTAVASIN
ActiveATCO LABORATORIES LIMITED
DML: PROSTAVASIN
Inj
1 additional record is present but flagged "Unverified / Legacy" and not listed.
