Aluminium Hydroxide and Oxide

Aluminum hydroxide is an antacid. It neutralizes and reduces stomach acidity and relieves heartburning and indigestion. Aluminium Hydroxide and Oxide is used to treat stomach upsets, ulcers or other digestive disorders. It may also be used to increase phosphate excretion when phosphate retention is associated with renal stones.

Aluminium Hydroxide and Oxide is primarily indicated in conditions like Heart burn, Peptic ulcer, Reflux esophagitis, Stress ulcers prevention, Calcinosis universalis, Hyperphosphataemia in renal failure, Nephrolithiasis.

Aluminium Hydroxide and Oxide is contraindicated in conditions like Renal failure,Osteomalacia,Partial intestinal obstruction.

The severe or irreversible adverse effects of Aluminium Hydroxide and Oxide, which give rise to further complications include Proximal myopathy, Encephalopathy, Dementia.The signs and symptoms that are produced after the acute overdosage of Aluminium Hydroxide and Oxide include Chronic constipation.The symptomatic adverse reactions produced by Aluminium Hydroxide and Oxide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Constipation, Chalky taste, Fecal Impaction, Stomach cramps, Osteomalacia

Aluminium hydroxide and oxide should be used with caution in patients with stomach disorders, allergies. Use in pregnancy if clearly needed.

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

250 to 1500 mg (880 (875)) 8 hourly PO —

No child dosage information is recorded for this medicine yet.

64 to 128 mg/kg (96 (96)) 6 hourly oral —

Aluminium Hydroxide and Oxide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlfacalcidolit increases or potentiate hypercalcemiaAzithromycinPeak serum drug concentration of azithromycin is decreased.Azithromycin should be given 1 hour before or after 2 hour of antacid.CalcitriolCarbenoxolone (Na)CefpodoximeCeftibutenTake antacid a part from the doses of ceftibutin.Chenodeoxycholic AcidChlordiazepoxide (HCl)ChloroquineCimetidine (HCl)Citric AcidClopidogrelAluminium Hydroxide and Oxide do not appear to affect serum concentration of Clopidogrel. N/ANo action required.DeferasiroxDeflazacortDiacereinDecreased absorption with aluminium and/or magnesium hydroxide antacids. Take with at least two hours difference.DiflunisalDiflunisalDigoxinAluminium hydroxide may decrease the serum concentration of digoxin.MinorNo action required.Ethambutol (HCl)Etidronate (Disodium)FluorideHydroxychloroquine (Sulphate)IndomethacinIron SaltsIsoniazidKetoconazoleLevofloxacinAluminium and magnesium hydroxide containing antacids, and products containing calcium, ion and zinc salts reduce the absorption of levofloxacin.MeclofenamateConcomitant administration of aluminum hydroxides does not interfere with absorption of meclofenamate sodium.NaproxenNorfloxacinOfloxacinOlanzapineOxethazaine The use of aluminum containing antacids is contraindicated in patients with symptoms of appendicitis since these products may increase the danger of perforation or rupture due to their constipating or laxative effects.Phenylbutazone Prednisolone and Prednisone Aluminium Hydroxide and Oxide impair absorption of prednisolone and prednisonePropranolol (HCl)Pseudoephedrine (HCl)aluminium hydroxide incerases the absorbtion of Pseudoephedrine (HCl)RanitidineRifampicinRisedronate (Na)Aluminium Hydroxide and Oxide will interfere with the absorption of Risedronate (Na).SimethiconeThis interaction is sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. Sodium ClodronateSodium Polystyrene SulphonateSTRONTIUM RANELATEA 20-25% decrease in the extent of oral strontium ranelate absorption is documented with aluminium/magnesium hydroxide, when given simultaneously or two hours before strontium. Absorption was negligibly affected with administration of the antacid two hours after strontium.MinorAdminister antacids two hours after strontium ranelate. Strontium ranelate is best taken at bedtime. Strontium-89 ChlorideSaturation of bone-binding sites by calcium may reduce uptake of strontium-89 chloride. ModerateSulfolaxSulfolax docusate may increase the toxicity of Aluminium Hydroxide and Oxide by increasing intestinal absorption of the drug. ModerateConcurrent use should be avoided.TadalafilSimultaneous administration of an antacid aluminium hydroxide and oxide and tadalafil reduced the apparent rate of absorption of tadalafil without altering exposure (AUC) to tadalafil.Technetium Tc-99m OxidronateHigh blood concentrations of aluminum ion, which may occur in patients with gastrointestinal obstruction or impaired renal function, may cause localization of technetium Tc 99m oxidronate in the liver.Tetracycline (HCl)Tetracycline (HCl)Thiamine HCl (Vitamin B1)Antacids may lower thiamin levels in the body by decreasing absorption and increasing excretion or metabolism.Zalcitabine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Tab, Susp Store in a well closed container, Below 40°C. Protect from Sunlight, Moisture and Heat.