Amifostine

Amifostine is used to help prevent or lessen some of the side effects of cisplatin (a cancer medicine) or radiation therapy on the kidneys and salivary glands. This medicine is to be given only by or under the immediate supervision of your doctor.

Amifostine is used to help prevent or lessen some of the side effects of cisplatin (a cancer medicine) or radiation therapy on the kidneys and salivary glands. This medicine is to be given only by or under the immediate supervision of your doctor.

Amifostine is contraindicated in conditions like Cardiac arrhythmia, Heart failure, Hypocalcemia, Hypotension, Cerebrovascular disease, Dehydration.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Blurred vision confusion dizziness, faintness, or lightheadedness when suddenly getting up from a lying or sitting position fainting or loss of consciousness fast or irregular breathing itching nausea, vomiting red, scaly, swollen, or peeling areas of the skin skin rash sweating swelling of the eyes or eyelids tightness in the chest trouble with breathing unusual tiredness or weakness Rare Blistering, peeling, or loosening of the skin burning or tingling sensation chills cough cracks in the skin diarrhea fast, slow, or irregular heartbeat or pulse fever joint or muscle pain loss of bladder control loss of heat from the body muscle cramps in the hands, arms, feet, legs, or face muscle spasm or jerking of all extremities no blood pressure or pulse numbness and tingling around the mouth, fingertips, or feet red, irritated eyes red skin lesions, often with a purple center seizures sore throat sores, ulcers, or white spots in the mouth or on the lips stomach cramps stopping of the heart sudden loss of consciousness tremor Incidence not known Bloody urine decreased frequency or amount of urine difficulty with swallowing hives or welts hoarseness increased blood pressure increased thirst lower back or side pain loss of appetite pain or discomfort in the arms, jaw, back, or neck slow or irregular breathing swelling of the face, fingers, or lower legs weight gain Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less common or rare Feeling unusually warm or cold flushing or redness of the face or neck headache hiccups nervousness pounding in the ears sleepiness (severe) sneezing Incidence not known Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

" Tell your doctor and pharmacist if you are allergic to Amifostine. Women who are pregnant or breast-feeding should tell their doctors before they begin taking this drug. You should know that the most common side effect of Amifostine is a decrease in blood pressure, which may start while the drug is being given and lasts about 6 minutes. Do not breast feed while taking this medication. For both men and women: Do not conceive a child (get pregnant) while taking Amifostine. Barrier methods of contraception, such as condoms, are recommended Discontinue Antihypertensive drugs 24 hours before starting Amifostine.

Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and Geriatrics. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

740 to 910 mg/m.sq (820 (825)) As recommended. IV — For cisplatin-induced renal toxicity: once daily 30min prior to cytotoxic therapy.

200 to 200 mg/m2/day (200 (200)) As recommended. IV-Inf — 740 to 740 mg/m2 (740 (740)) As recommended. IV — To reduce cisplatin induced renal toxicity, if doses of cisplatin of less than 100mg/m2 are used. Gi

No neonatal dosage information is recorded for this medicine yet.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

No storage information is recorded for this medicine yet.