Amoxapine
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Amoxapine is a tricyclic antidepressant that is used to treat symptoms of depression, anxiety, or agitation.
Amoxapine may also be used for purposes not listed in this medication guide.
Indications
Amoxapine is a tricyclic antidepressant that is used to treat symptoms of depression, anxiety, or agitation.
Amoxapine may also be used for purposes not listed in this medication guide.
Contraindications
You should not use amoxapine if you are allergic to it, or if:
you have recently had a heart attack.
Do not use trimipramine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks , such as citalopram , escitalopram , fluoxetine (Prozac), fluvoxamine , paroxetine, sertraline (Zoloft), trazodone, or vilazodone.
Tell your doctor if you have ever had:
heart disease , stroke, or seizures; kidney disease; schizophrenia or other mental illness; diabetes (amoxapine may raise or lower blood sugar); bipolar disorder ( manic depression ); if you are receiving electroshock treatment; glaucoma; or problems with urination.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Tell your doctor if you are pregnant or breastfeeding.
Amoxapine is not approved for use by anyone younger than 18 years old.
Side Effects
Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor , such as: mood or behavior changes, anxiety, panic attacks , trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Amoxapine may cause serious side effects. Call your doctor at once if you have:
skin rash, fever; uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); pounding heartbeats or fluttering in your chest; chest pain or pressure, pain spreading to your jaw or shoulder; sudden numbness or weakness (especially on one side of the body), slurred speech, problems with vision or balance; or severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.
Common side effects of amoxapine may include:
drowsiness; constipation ; dry mouth; or blurred vision.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
You should not use amoxapine if you have recently had a heart attack .
Do not use amoxapine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid , linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine .
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor .
High Risk Groups
You should not use amoxapine if you have recently had a heart attack .
Do not use amoxapine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid , linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine .
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor .
Adult Dosage
200 to 300 mg/day (250 (250)) As recommended. PO — Three weeks constitutes an adequate period of trial providing dosage has reached 300 mg daily (or lower level of tolerance) for at least two weeks. If no response is seen at 300 mg, dosage may be increased, depending upon tolerance, up to 400 mg daily. Hospitalized patients who have been refractory to antidepressant therapy and who have no history of convulsive seizures may have dosage raised cautiously up to 600 mg daily in divided doses. Amoxapine may be given in a single daily dose, not to exceed 300 mg, preferably at bedtime. If the total daily dosage exceeds 300 mg, it should be given in divided doses.
Scraped Dose — Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
If you take amoxapine once daily, take your dose at bedtime.
It may take up to 3 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
Do not stop using amoxapine suddenly , or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using trimipramine .
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Using amoxapine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Many drugs can affect amoxapine. This includes prescription and over-the-counter medicines, vitamins, and herbal products . Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Storage
Tab Store at room temperature.
Available Brands in Pakistan
No brands are recorded for this generic.
