Anistreplase
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Anistreplase is a thrombolytic drug. It is also known as Anisoylated plasminogen streptokinase activator complex (APSAC) It consists of a complex of purified human plasminogen and bacterial streptokinase that has been acylated to protect the active site of the enzyme. It prevents blood from clotting. Anistreplase is used in the treatment of deep vein thrombosis and pulmonary embolism. Anistreplase is effective in reducing the risk of death following an acute heart attack. It may produce allergic reactions.
Indications
Anistreplase is primarily indicated in conditions like Myocardial infarction.
Contraindications
Anistreplase is contraindicated in conditions like Hypertension, Peptic ulcer, Cardiac stroke, Vaginal bleeding, Chest compression, Intracranial neoplasm, Diabetic retinopathy, Hemorrhagic diathesis.
Side Effects
The severe or irreversible adverse effects of Anistreplase, which give rise to further complications include Allergic reactions. Anistreplase produces potentially life-threatening effects which include Bleeding, which are responsible for the discontinuation of Anistreplase therapy. The signs and symptoms that are produced after the acute over dosage of Anistreplase include Hemorrhage. The symptomatic adverse reactions produced by Anistreplase are more or less tolerable and if they become severe, they can be treated symptomatically, these include Mild flushing, Shaking, Tight breathing.
Warnings
Anistreplase should be used with caution in patients with bleeding, blood vessel abnormalities, brain tumor, history of stroke, recent surgery, extremely high blood pressure (200/120mm ofHg or higher). This drug should be used with caution when the following conditions exist: child birth with in 10days, blood-clotting problems, retinal bleeding (recent) gastrointestinal or urinary tract bleeding (recent), ulcer, recent invasive medical procedure or any heart abnormalities.
High Risk Groups
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
30 IU (30 (30)) As recommended. Slow IV — As Required
Child Dosage
Not Indicated in this Age Group ( ) —
Neonatal Dosage
Not recomended in this age group ( ) —
Drug Interactions
Anistreplase is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementTenecteplaseConcurrent use is usually not recommended but may be required in some cases. If both medicines are prescribed together, change of dose may be required. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Inj (reconstituted soln) Store at room temperature. Use within 30 min if kept at room temperature. Powder for Inj Store in refrigerator.
Available Brands in Pakistan
No brands are recorded for this generic.