Apomorphine

Apomorphine belongs to a class of drugs called dopamine agonists. It is used to treat a progressive nervous system disorder that affects movement called Parkinson's disease . Dopamine agonist, such as apomorphine, are medications that mimic the action of dopamine. Dopamine is produced by the brain and acts as a messenger or neurotransmitter sending information between nerve cells (neurons). Apomorphine works to help treat Parkinson's disease by binding to dopamine receptors in the brain and acting like natural dopamine. Low levels of dopamine are thought to cause the symptoms of Parkinson's disease. Apomorphine comes in the form of a: Subcutaneous injection - an injection that you inject under your skin. This form of the drug is available under the brand name Apokyn and a generic version is also available. Sublingual film - a film you put under your tongue. This form of the drug is available under the brand name Kynmobi. Generic versions of a sublingual film have not been approved Subcutaneous infusion device - a small and lightweight wearable device that delivers a continuous infusion of apomorphine under the brand name Onapgo. A generic version is not available. Apomorphine was approved by the US Food and Drug Administration (FDA) in 2004.

Apomorphine belongs to a class of drugs called dopamine agonists. It is used to treat a progressive nervous system disorder that affects movement called Parkinson's disease . Dopamine agonist, such as apomorphine, are medications that mimic the action of dopamine. Dopamine is produced by the brain and acts as a messenger or neurotransmitter sending information between nerve cells (neurons). Apomorphine works to help treat Parkinson's disease by binding to dopamine receptors in the brain and acting like natural dopamine. Low levels of dopamine are thought to cause the symptoms of Parkinson's disease. Apomorphine comes in the form of a: Subcutaneous injection - an injection that you inject under your skin. This form of the drug is available under the brand name Apokyn and a generic version is also available. Sublingual film - a film you put under your tongue. This form of the drug is available under the brand name Kynmobi. Generic versions of a sublingual film have not been approved Subcutaneous infusion device - a small and lightweight wearable device that delivers a continuous infusion of apomorphine under the brand name Onapgo. A generic version is not available. Apomorphine was approved by the US Food and Drug Administration (FDA) in 2004.

Apomorphine is contraindicated in conditions like Respiratory disease, Cardiac disease, Opioid dependence.

The severe or irreversible adverse effects of Apomorphine, which give rise to further complications include Delayed psychosis. Apomorphine produces potentially life-threatening effects which include Uremia, Asystole. which are responsible for the discontinuation of Apomorphine therapy. The signs and symptoms that are produced after the acute overdosage of Apomorphine include Postural hypotension, Peripheral vasodilation, Protracted vomiting, Acute psychosis. The symptomatic adverse reactions produced by Apomorphine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Hallucination, Edema, Reaction at injection site.

It should be used with caution in patient prone to vomiting and nausea or when vomiting is likely to pose a risk, use with care in patient with pulmonary, cardiovascular, endocrine disease or with renal impairment. Extra care is needed during initiation of treatment in elderly or debilitated patient and in those with a history of postural hypotension. Periodic monitoring of renal, hepatic, hemopoietic and cardiovascular function has been advised. Patient who develop anemia or those who have continuing confusion or hallucination during treatment require observation and dosage adjustment under specialist supervision, treatment may need to be discontinue.

Drug should not be given to Paediatrics, Cardiac / Hypertensive Patients, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

No adult dosage information is recorded for this medicine yet.

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using apomorphine with certain other medicines may affect each other. Using apomorphine with other medicines can cause serious side effects. If you take nitroglycerin under your tongue while using apomorphine, your blood pressure may decrease and cause dizziness. After taking nitroglycerin, you should lie down and try to continue lying down for at least 45 minutes. You should avoid standing for 45 minutes after taking nitroglycerin. Know the medicines you take. Keep a list to show your healthcare provider or pharmacist when you get a new medicine.

SC Inj, SC Inf Store Below 25°C. Protect from Sunlight.