This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Aprepitant is used together with other medications to prevent nausea and vomiting that may be caused by chemotherapy.
Aprepitant may also be used in adults to prevent nausea and vomiting after surgery .
Aprepitant is not used to treat nausea and vomiting that you already have.
Aprepitant capsules are for use in adults and children who are at least 12 years old. Aprepitant oral suspension ( liquid ) can be given to adults and children as young as 6 months old.
Aprepitant may also be used for purposes not listed in this medication guide.
Indications
Aprepitant is used together with other medications to prevent nausea and vomiting that may be caused by chemotherapy.
Aprepitant may also be used in adults to prevent nausea and vomiting after surgery .
Aprepitant is not used to treat nausea and vomiting that you already have.
Aprepitant capsules are for use in adults and children who are at least 12 years old. Aprepitant oral suspension ( liquid ) can be given to adults and children as young as 6 months old.
Aprepitant may also be used for purposes not listed in this medication guide.
Contraindications
You should not use aprepitant if you are allergic to it.
Some drugs should not be used with aprepitant. Your treatment plan may change if you also use pimozide .
Tell your doctor if you have ever had:
to use a blood thinner (or a medicine called warfarin ) and you have routine "INR" or prothrombin time tests; or severe liver disease .
Aprepitant may harm an unborn baby. Tell your doctor if you are pregnant.
Ask a doctor if it is safe to breastfeed while using aprepitant.
Aprepitant can make hormonal birth control less effective, including birth control pills , injections, implants, skin patches, and vaginal rings. Use barrier birth control to prevent pregnancy: condom, diaphragm, cervical cap, spermicide, or contraceptive sponge.
Ask your doctor about the best form of birth control while you are using aprepitant.
Keep using the barrier form of birth control for 1 month after your last dose of aprepitant.
Side Effects
Get emergency medical help if you have signs of an allergic reaction : hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache , chest tightness, back pain , trouble breathing, or swelling in your face.
Aprepitant may cause serious side effects. Call your doctor at once if you have:
worsening of your skin condition, skin peeling or sores; a light-headed feeling, like you might pass out; or fast or slow heart rate .
Common side effects of aprepitant may include:
stomach pain or discomfort, burping, loss of appetite; low blood pressure , headache, dizziness; low blood cell counts; diarrhea , constipation ; hiccups , cough; abnormal liver function tests; dehydration ; urinary tract infection ; pain, weakness, or numbness in your arms or legs; or feeling weak or tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
Tell your doctor about all your other medicines. Some drugs should not be used with aprepitant.
High Risk Groups
Tell your doctor about all your other medicines. Some drugs should not be used with aprepitant.
Adult Dosage
40 to 40 mg (40 (40)) As recommended. PO — For prevention of postoperative nausea and vomiting (PONV): The recommended oral dosage of aprepitant is 40 mg within 3 hours prior to induction of anesthesia.
80 to 125 mg (100 (102.5)) As recommended. PO — Aprepitant is given for 3 days as part of a regimen that includes a corticosteroid and a 5-HT3 antagonis for moderate to highly emetogenic cancer chemotherapy:. The recommended dose of aprepitant is 125 mg orally 1 hour prior to chemotherapy treatment (Day 1) and 80 mg orally once daily in the morning on Days 2 and 3.
It may be taken with or with out food.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.
Many drugs can affect aprepitant. This includes prescription and over-the-counter medicines, vitamins , and herbal products . Not all possible interactions are listed here. Tell your doctor about all other medicines you use.