Azapropazone
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Azapropazone is a non-steroidal anti-inflammatory drug (NSAID). Azapropazone is a weak inhibitor of cyclooxygenase, but possesses potent uricosuric activity, therefore particularly useful for the treatment of acute gout. Azapropazone is also used for the treatment of rheumatoid arthritis, osteoarthritis.
Indications
Azapropazone is primarily indicated in conditions like Acute gout attack, Rheumatoid arthritis.
Contraindications
Azapropazone is contraindicated in conditions like Peptic ulcer, Blood disorders.
Side Effects
The severe or irreversible adverse effects of Azapropazone, which give rise to further complications include Hepatitis, Pulmonary fibrosis, Erythema multiforme, Agranulocytosis. Azapropazone produces potentially life-threatening effects which include Autoimmune hemolysis, Non-oliguric renal failure, Coombs +ive hemolytic anemia, Acute intestinal nephritis. which are responsible for the discontinuation of Azapropazone therapy. The symptomatic adverse reactions produced by Azapropazone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Photosensitivity.
Warnings
It should not be given in patient with peptic ulceration and should be used with caution in patient with a history of such disorders and with infection, asthma or allergic disorder, impaired renal, hepatic or cardiac function, in elderly and may need to be given in reduce doses. To reduce he risk of gastrointestinal effects, the drug may be taken with or after food or milk.
High Risk Groups
Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
600 mg (600 (600)) 12 hourly PO — The dose can be decreased to 900mg/day and incresed upto 1800mg/day.
For renal impaired function: Starting dose is 300mg in the morning and 600 mg at night.
For much older patients(more than 65 years):Starting dose is 600mg at night or 300 mg twice daily.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Azapropazone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCyclosporin AFosphenytoinLithiumMethotrexatePhenytoin (Na)TacrolimusWarfarin (Na)Anticoagulant effect seriously enhanced by azapropazone.AVOID CONCOMITANT USE.Zidovudine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Caps, Tabs Store . Protect from Sunlight, Moisture and Heat.
Available Brands in Pakistan
No active brands are currently recorded for this generic.
1 record is present but flagged "Unverified / Legacy" and excluded.