Bacillus Clausii

Probiotics are intended to assist the body's natural gut microbiota.( WGO 2017 ) The potential mechanisms by which probiotics exert their action include production of pathogen-inhibitory substances, inhibition of pathogen attachment, inhibition of the action of microbial toxins, stimulation of immunoglobulin A, and trophic effects on intestinal mucosa. Each agent or preparation may have unique actions, with some bacterial strains being more or less effective than others. Trials included in meta-analyses are generally heterogeneous, especially with respect to the strain of probiotic used.( Di Caro 2005 , Hill 2013 , Oelschlaeger 2010 , Ohland 2010 ) See also the Probiotics monograph. Studies of preparations containing B. clausii spores support its use for the treatment and prevention of gut barrier impairment.( Lopetuso 2016 ) In contrast to lactic acid probiotics such as lactobacilli and bifidobacteria, the spore-forming Bacillus spp. probiotics are extremely resistant to acid and heat. B. clausii is characterized by some unique properties, including its resistance to bile and gastric acids, and its ability to grow in high-salt concentrations, adhere to the intestinal wall, promote epithelial proliferation, and survive transit through the GI tract. As a commercial product, these unique characteristics allow B. clausii to be stored without refrigeration or in a desiccated form without negatively affecting its viability.( Ghelardi 2015 , Upadrasta 2016 ) Other attributes of Bacillus spp. include colonization, immunostimulation, and antimicrobial properties. B. clausii is resistant to commonly used antibiotics and demonstrates intrinsic resistance to penicillins, cephalosporins, aminoglycosides, and macrolides. It exhibits acquired resistance to tetracycline and chloramphenicol, and resistance to rifampin due to a chromosomal mutation. Resistance to lincomycin, isoniazid, cycloserine, and nalidixic acid has also been reported. B. clausii strains have been observed to release antimicrobial substances that are active against Staphylococcus aureus, Enterococcus faecium, and Clostridium difficile. B. clausii is capable of producing various vitamins, in particular the group B vitamins.( Di Caro 2005 , Erceflora 2021 , Lopetuso 2016 ) Experimental studies reveal that B. clausii affects intestinal mucosa homeostasis via regulation of gene expression. In the small bowel mucosa, up- and down-regulation of genes involved in immune response and inflammation (eg, interleukin 1 [IL-1], IL-6, tumor necrosis factor, plasminogen activator), apoptosis, cell growth, and cell cycle (eg, RAS oncogenes, insulinlike growth factor, somatostatin), as well as cell adhesion, transcription, cell communication, and defense response functions, were observed.( Di Caro 2005 )

Probiotics are intended to assist the body's natural gut microbiota.( WGO 2017 ) The potential mechanisms by which probiotics exert their action include production of pathogen-inhibitory substances, inhibition of pathogen attachment, inhibition of the action of microbial toxins, stimulation of immunoglobulin A, and trophic effects on intestinal mucosa. Each agent or preparation may have unique actions, with some bacterial strains being more or less effective than others. Trials included in meta-analyses are generally heterogeneous, especially with respect to the strain of probiotic used.( Di Caro 2005 , Hill 2013 , Oelschlaeger 2010 , Ohland 2010 ) See also the Probiotics monograph. Studies of preparations containing B. clausii spores support its use for the treatment and prevention of gut barrier impairment.( Lopetuso 2016 ) In contrast to lactic acid probiotics such as lactobacilli and bifidobacteria, the spore-forming Bacillus spp. probiotics are extremely resistant to acid and heat. B. clausii is characterized by some unique properties, including its resistance to bile and gastric acids, and its ability to grow in high-salt concentrations, adhere to the intestinal wall, promote epithelial proliferation, and survive transit through the GI tract. As a commercial product, these unique characteristics allow B. clausii to be stored without refrigeration or in a desiccated form without negatively affecting its viability.( Ghelardi 2015 , Upadrasta 2016 ) Other attributes of Bacillus spp. include colonization, immunostimulation, and antimicrobial properties. B. clausii is resistant to commonly used antibiotics and demonstrates intrinsic resistance to penicillins, cephalosporins, aminoglycosides, and macrolides. It exhibits acquired resistance to tetracycline and chloramphenicol, and resistance to rifampin due to a chromosomal mutation. Resistance to lincomycin, isoniazid, cycloserine, and nalidixic acid has also been reported. B. clausii strains have been observed to release antimicrobial substances that are active against Staphylococcus aureus, Enterococcus faecium, and Clostridium difficile. B. clausii is capable of producing various vitamins, in particular the group B vitamins.( Di Caro 2005 , Erceflora 2021 , Lopetuso 2016 ) Experimental studies reveal that B. clausii affects intestinal mucosa homeostasis via regulation of gene expression. In the small bowel mucosa, up- and down-regulation of genes involved in immune response and inflammation (eg, interleukin 1 [IL-1], IL-6, tumor necrosis factor, plasminogen activator), apoptosis, cell growth, and cell cycle (eg, RAS oncogenes, insulinlike growth factor, somatostatin), as well as cell adhesion, transcription, cell communication, and defense response functions, were observed.( Di Caro 2005 )

Bacillus Clausii

No data regarding the side effects produced by Bacillus Clausii is available

No data regarding the Warnings/Precuations of Bacillus Clausii is available.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

No adult dosage information is recorded for this medicine yet.

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

None well documented.

No storage information is recorded for this medicine yet.