Benzylpenicillin (Na or K)

Benzylpenicillin (Na or K) is a BETA-LACTUM antibiotic and has a bactericidal action against gram-poisitve bacteria, gram-negative cocci, some other gram-negative bacteria, spirochetes, and actinomycetes. It exerts its killing action on growing and dividing bacteria by inhibiting bacterial cell wall synthesis.Benzylpenicillin (Na or K) is used in treatment of a variety of infections including abscess, actinomycosis, anthrax, bites and stings, diptheria etc.

Benzylpenicillin (Na or K) is primarily indicated in conditions like Bacterial endocarditis, Bacterial infections, Meningococcal disease, Muscle relaxation, Muscle relaxation for surgery or intubation, Penicillin sensitive infections.

Benzylpenicillin (Na or K)

The severe or irreversible adverse effects of Benzylpenicillin (Na or K), which give rise to further complications include Convulsions, Renal damage, Hemolytic anemia, Hypersensitivity reactions, Bone marrow hypoplasia, Jarisch herxheimer reaction, Cation intoxication.Benzylpenicillin (Na or K) produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Benzylpenicillin (Na or K) therapy.The symptomatic adverse reactions produced by Benzylpenicillin (Na or K) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin rash, Local reactions.

Benzylpenicillin should be used with caution in patients with history of allergy, especially to drugs and in patient hypersensitive to penicillin. Care is necessary if very high dose of penicillin is given, especially if renal (kidney) function is poor. Renal and hematological status should be monitored during prolonged and high dose therapy.

Drug should not be given to Pregnant Mothers, and Cardiac / Hypertensive Patients.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

85.71 to 171.42 mg/kg (130 (128.565)) 24 hourly IV — For 2-4 Weeks Scraped Dose — Instructions for the preparation of an intramuscular injection of a dose of 1,200,000 units of benzathine benzylpenicillin: The suspension must be prepared aseptically. 1/ With a graduated syringe for intramuscular injection (needle gauge: 22, 21 or 20), take 4 mL of water for injections from the ampule of diluent contained in the box. The compatibility data are only available with water for injectable preparations and 1% or 0.5% lidocaine injectable solution. Warning: the ampule of diluent provided in the box contains 5 mL of water for injections. It is not necessary to use all the contents for the preparation of this suspension. 2/ Into the vial of powder of 1,200,000 units, add the 4 mL of water for injections taken from the ampule of diluent, or the 4 mL of 1.0% or 0.5% lidocaine injectable solution. 3/ Agitate this suspension carefully for at least 20 seconds until a homogenous suspension is obtained, then use the suspension immediately as soon as it is prepared. The suspension obtained in this way corresponds to a dose of 1,200,000 units. This reconstitution must only be done for one single injection. For doses of Extencilline less than 1,200,000 units, withdraw the appropriate volume of the reconstituted product and discard the remainder. For example, withdraw half the volume of the reconstituted 1,200,000 units for a 600,000 units dose of Extencilline. Instructions for the preparation of an intramuscular injection of a dose of 2,400,000 units of benzathine benzylpenicillin: The suspension must be prepared aseptically. 1/ With a graduated syringe for intramuscular injection (needle gauge: 22, 21 or 20), take 5 mL of water for injections from the ampule of diluent contained in the box, or 5 mL of 1% or 0.5% lidocaine injectable solution. 2/ Into the vial of powder 2,400,000 units, add the 5 mL of water for injections taken from the ampule of diluent, or 5 mL of 1% or 0.5% lidocaine injectable solution. 3/ Agitate this for suspension carefully for at least 20 seconds until a homogenous for suspension is obtained, then use the for suspension immediately as soon as it is prepared. The suspension obtained in this way corresponds to a dose of 2,400,000 units. This reconstitution must only be done for one single injection. For doses of Extencilline less than 2,400,000 units, withdraw the appropriate volume of the reconstituted product and discard the remainder.

25 to 50 mg/kg (38 (37.5)) 6 hourly Intra Venous — -

25 to 50 mg/kg (38 (37.5)) 6 hourly Intravenous —

Benzylpenicillin (Na or K) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementColestipol (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Inj Store in a well closed container, at room temperature, Below 30°C.