Bethanidine (Sulphate)
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Bethanidine (Sulphate) is used in hypertension to reduce the blood pressure.its actions and uses are similar to those of guanethidine monosulphate but it causes less depletion of noradrenaline stores. It also has a more rapid onset, together with a shorter duration of action, than guanethidine.
Indications
Bethanidine (Sulphate) is primarily indicated in conditions like Hypertension.
Contraindications
Bethanidine (Sulphate) is contraindicated in conditions like Phaeochromocytoma,Renal failure.
Side Effects
The severe or irreversible adverse effects of Bethanidine (Sulphate), which give rise to further complications include Diarrhoea, Thrombocytopenia, Impotence.Bethanidine (Sulphate) produces potentially life-threatening effects which include Severe Hypotension, Myocardial infarction, Angina pectoris, Cerebrovascular insufficiency, Syncope, Cerebral infarction. which are responsible for the discontinuation of Bethanidine (Sulphate) therapy.The signs and symptoms that are produced after the acute over dosage of Bethanidine (Sulphate) include Bradycardia, Postural hypotension, Dizziness, Fainting.The symptomatic adverse reactions produced by Bethanidine (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vomiting, Nasal stiffiness.
Warnings
Bethanidine (beta-blocker) should not be given to patients with bronchospasm, asthma, with history of obstructive airway disease, metabolic acidosis, partial heart block, sinus bradycardia or psoriasis. The dose may need to reduce in patients with renal (kidney) or hepatic (liver) dysfunction. Patients with long term treatment with beta-blockers should have their medication discontinued gradually over a period of 1 to 2 weeks, because it may result in angina, myocardial infraction (MI), ventricular arrhythmia or death. This drug should be used only if clearly needed during pregnancy or lactation.
High Risk Groups
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
0.114 to 0.228 mg/kg (0.17 (0.171)) 8 hourly PO — Maintenance, As Required.
0.228 mg/kg (0.23 (0.228)) 8 hourly PO — Initial
Child Dosage
Rarely used in this Age Group ( ) —
Neonatal Dosage
( ) — Not recommended in this age group
Drug Interactions
Bethanidine (Sulphate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholAmitriptyline (HCl)Chlorpromazine (HCl)Desipramine (HCl)Dothiepin (HCl)Doxepin (HCl)Imipramine (HCl)Trimipramine (Maleate) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Tabs Store Between 20°C-25°C.
Available Brands in Pakistan
No brands are recorded for this generic.