Bovine Insulin

Insulin is a hormone produced by the beta cells of the islets of Langerhans of the pancreas and consists of 2 chains of amino acids. It contains 51 amino acid arranged in two chains (A and B) joined together by disulfide linkage. In 1921, Banting and Best extracted insulin from the pancreas and demonstrated its therapeutic effects in diabetic dogs and human subjects.

Bovine Insulin is primarily indicated in conditions like Diabetes mellitus, Hyperkalemia.

Bovine Insulin is contraindicated in conditions like Hypersensitivity.

Bovine Insulin produces potentially life-threatening effects which include Hypoglycemia, which are responsible for the discontinuation of Bovine Insulin therapy.The symptomatic adverse reactions produced by Bovine Insulin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Allergy, Lipoatrophy, Antibody formation.

It should be used with caution in case of bovine hypersensitivity, breast feeding, coma, diarrhea, fever, infections, porcine hypersensitivity, renal impairment, surgery, thyroid disease, trauma, and vomiting.

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Geriatrics. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

0.1 to 0.4 IU/ kg (0.25 (0.25)) 24 hourly IV — 5 to 10 IU (7.5 (7.5)) 24 hourly SC — Dose should be adjusted according to patient's blood glucose level.

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Bovine Insulin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholCaptoprilACE inhibitors (e.g Captopril) possibly enhance hypoglycemic effect of insulin. Chlorpromazine (HCl)Clonidine (HCl)CyclophosphamideDanazolIsoniazid These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

IM Inj, SC Inj, IV Inf Store at room temperature or refrigerator. Do not Freeze. Protect from Sunlight. Use within 2 yrs (at4C) if refrigerated and within 1 month if kept at room temperature. Powder Store in a well closed container. Freezing is recommended. Protect from Sunlight.