Bupivacaine (HCl)

Exparel (bupivacaine) is an anesthetic (numbing medicine) that is used after surgery to provide: Local analgesia (pain relief in a small area) via infiltration for adults and children aged 6 and older Regional analgesia (pain relief in a larger area) in adults via: An interscalene brachial plexus nerve block A sciatic nerve block in the popliteal fossa An adductor canal block. Exparel contains the local anesthetic bupivacaine that works to produce postsurgical analgesia by blocking the generation and the conduction of nerve impulses. Exparel uses the DepoFoam® proprietary multivesicular liposome (pMVL) technology to deliver bupivacaine for an extended period, providing analgesia for up to 72 hours after a single dose. Exparel was first FDA-approved on October 28, 2011.

Exparel (bupivacaine) is an anesthetic (numbing medicine) that is used after surgery to provide: Local analgesia (pain relief in a small area) via infiltration for adults and children aged 6 and older Regional analgesia (pain relief in a larger area) in adults via: An interscalene brachial plexus nerve block A sciatic nerve block in the popliteal fossa An adductor canal block. Exparel contains the local anesthetic bupivacaine that works to produce postsurgical analgesia by blocking the generation and the conduction of nerve impulses. Exparel uses the DepoFoam® proprietary multivesicular liposome (pMVL) technology to deliver bupivacaine for an extended period, providing analgesia for up to 72 hours after a single dose. Exparel was first FDA-approved on October 28, 2011.

You should not be treated with Exparel if you are allergic to bupivacaine. Before receiving Exparel, tell your doctor if you have had: an allergic reaction to any type of numbing medicine liver disease kidney disease heart disease a heart rhythm disorder or seizures. May cause fetal harm. Tell your doctor if you are pregnant. It may not be safe to breastfeed a baby while you are using this medicine. Ask your doctor about any risks.

Bupivacaine (HCl) produces potentially life-threatening effects which include Respiratory depression, Respiratory arrest. which are responsible for the discontinuation of Bupivacaine (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Bupivacaine (HCl) include Metallic taste, Tinnitus, Anxiety, Irrational behavior, Circumoral numbness, Visible brusin .The symptomatic adverse reactions produced by Bupivacaine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Anxiety, Tinnitus, Metallic taste, Shivering, Circumoral numbness, Somnolence, Pruritus generalized, Paresthesia, Dysgeusia, Dysuria, Diarrhea, Insomnia, Flatulence, ECG T wave inversion, Muscle twitching.

Do not use for obstetrical paracervical block anesthesia. The safety and effectiveness of Exparel have not been established for postsurgical regional analgesia via other nerve blocks besides the ones approved above. Your healthcare provider will monitor your cardiovascular status, neurological status, and vital signs during and after injection of Exparel. Call your doctor if you have joint pain or stiffness, or weakness in any part of your body that occurs after your surgery, even months later. Should be used cautiously in people with liver disease because Exparel is metabolized by the liver. Patients with severe hepatic disease are at a greater risk of developing toxic plasma concentrations. Cases of methemoglobinemia (a rare blood disorder that affects how red blood cells deliver oxygen throughout your body) have been reported in association with local anesthetic use. Seek immediate medical attention if they or someone in their care experience the following signs or symptoms: pale, gray, or blue-colored skin (cyanosis); headache; rapid heart rate; shortness of breath; lightheadedness; or fatigue. Avoid using other local anesthetics within 96 hours of Exparel. Because of the liposomal formulation, Exparel is not substitutable with other bupivacaine products even if the strength is the same. You may still feel numb or be unable to move the numbed area for up to 5 days after you are treated with Exparel.

Do not use for obstetrical paracervical block anesthesia. The safety and effectiveness of Exparel have not been established for postsurgical regional analgesia via other nerve blocks besides the ones approved above. Your healthcare provider will monitor your cardiovascular status, neurological status, and vital signs during and after injection of Exparel. Call your doctor if you have joint pain or stiffness, or weakness in any part of your body that occurs after your surgery, even months later. Should be used cautiously in people with liver disease because Exparel is metabolized by the liver. Patients with severe hepatic disease are at a greater risk of developing toxic plasma concentrations. Cases of methemoglobinemia (a rare blood disorder that affects how red blood cells deliver oxygen throughout your body) have been reported in association with local anesthetic use. Seek immediate medical attention if they or someone in their care experience the following signs or symptoms: pale, gray, or blue-colored skin (cyanosis); headache; rapid heart rate; shortness of breath; lightheadedness; or fatigue. Avoid using other local anesthetics within 96 hours of Exparel. Because of the liposomal formulation, Exparel is not substitutable with other bupivacaine products even if the strength is the same. You may still feel numb or be unable to move the numbed area for up to 5 days after you are treated with Exparel.

50 to 100 mg (75 (75)) As recommended. Intra Thecal — As Required

1.25 mg/kg (1.2 (1.25)) As recommended. Intra Thecal — As Required

1.25 mg/kg (1.2 (1.25)) As recommended. Intra Thecal — As Required

Other drugs may interact with Exparel, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using including: Lidocaine or other non-bupivacaine local anesthetics: Do not mix. Exparel may be administered at least 20 minutes or more following local administration of lidocaine Bupivacaine HCl: Do not exceed a milligram dose of bupivacaine HCl solution to Exparel of 1:2 when admixing, as this may impact the pharmacokinetics and/or physicochemical properties of the drugs.

Inj Store at room temperature. Do not Freeze. Protect from Sunlight.