Medicines/Generics/Buprenorphine (HCl)

Buprenorphine (HCl)

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Buprenorphine (HCl) is a synthetic derivative of thebaine. Buprenorphine (HCl) is narcotic analgesic. Buprenorphine (HCl) is used to relieve the moderate to severe pain and as an adjunct to anesthesia.

Indications

Buprenorphine (HCl) is primarily indicated in conditions like Adjunct in the treatment of opioid dependence, Adjunct to prevent relapse, Advanced breast cancer in postmenopausal women, All forms of epilepsy, Cocaine withdrawal, Moderate to severe acute pain, Moderate to severe chronic pain, Moderate to severe pain, Myoclonus, Opioid agonist dependence, Post operative analgesia.

Contraindications

Buprenorphine (HCl) is contraindicated in conditions like Hypersensitivity, Pheochromocytoma, Respiratory disease, Paralytic ileus, Head injury, Atrophic oral candidiasis associated with dentures.

Side Effects

The severe or irreversible adverse effects of Buprenorphine (HCl), which give rise to further complications include Hallucinations. Buprenorphine (HCl) produces potentially life-threatening effects which include Respiratory depression. which are responsible for the discontinuation of Buprenorphine (HCl) therapy. The symptomatic adverse reactions produced by Buprenorphine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Headache, Nausea, Vomiting, Constipation, Sweating, Insomnia, Back pain, Abdominal pain, Asthenia, Constipation, Rhinitis, Chills, Flu syndrome.

Warnings

Buprenorphine should be used with caution and in low doses in patients with lungs, liver or kidney impairment, central nervous system (CNS) depression or patients undergoing biliary tract surgery. Patients should observe caution while driving or performing tasks requiring alertness, because it may cause drowsiness.

High Risk Groups

Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

0.3 to 0.6 mg (0.45 (0.45)) 8 hourly IV,IM — 0.4 to 0.2 mg (0.3 (0.3)) 8 hourly PO —

Child Dosage

3 to 9 ug/kg (6 (6)) 8 hourly Intra Muscular — - 3 to 9 ug/kg (6 (6)) 8 hourly Intra Venous — -

Neonatal Dosage

3 to 9 ug/kg (6 (6)) 8 hourly Intramuscular — 3 to 9 ug/kg (6 (6)) 8 hourly Intravenous —

Drug Interactions

Buprenorphine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAlfentanil (HCl)Naloxone (HCl)VORICONAZOLEVoriconazole may increase the serum concentration of buprenorphine by decreasing its metabolismMonitor for changes in the therapeutic and adverse effects of budesonide if voriconazole is initiated, discontinued or dose changed. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Storage

Inj Store Below 40°C. Do not Freeze. Protect from Sunlight.

Available Brands in Pakistan

18 active brands listed alphabetically.

Buprenorphine (HCl)

Available Brands in Pakistan

BUEPRON

BUNORFIN

BUPER

BUPREGESIC

DORFENE

GESIC

GESNOR

MOMMI

OPINOR

ORGESIC

PRENOR

PROZEM

RUKGASEE

SEGESIC

SEMOXIN

TEMFIN

TEMGO

ZONOR