Ceftizoxime (Na)
Generic medicine reference
Overview
Ceftizoxime is a third generation, semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporanic acid and are closely related to penicillin in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Ceftizoxime is a broad spectrum, ß lactamase resistant antibiotic effective against a wide range of aerobic and anaerobic gram positive and gram negative bacteria. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Ceftizoxime (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Indications
Ceftizoxime (Na) is primarily indicated in conditions like Bacteremia, Genitourinary tract infections, Intra-abdominal infections, Lower respiratory tract infections, Septicemia, Skin infections, Soft tissue infections, and can also be given in adjunctive therapy as an alternative drug of choice in Bacterial infections, Bone and joint infection, Gonorrhea, Gynecological infections, Meningitis, Surgical prophylaxis.
Contraindications
Ceftizoxime (Na) is contraindicated in conditions like Hypersensitivity to any component of product.
Side Effects
The severe or irreversible adverse effects of Ceftizoxime (Na), which give rise to further complications include Thrombocytopenia, Hypersensitivity reactions, Eosinophilia, Leucopenia, Neutropenia, Thrombocytosis. Ceftizoxime (Na) produces potentially life-threatening effects which include Pseudomembranous colitis, Anaphylaxis, Diarrhea. which are responsible for the discontinuation of Ceftizoxime (Na) therapy. The symptomatic adverse reactions produced by Ceftizoxime (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Fever, Rashes, Pruritus, Local reactions, Nausea and vomiting, Elevated alkaline phosphatase, Elevated SGPT & SGOT.
Warnings
Ceftizoxime should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs.
High Risk Groups
Drug should not be given to patients suffering from Kidney dysfunction. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
1000 to 2000 mg (1500 (1500)) 12 hourly IM/IV —
Child Dosage
50 mg/kg (50 (50)) 8 hourly Intra Muscular — -
50 mg/kg (50 (50)) 8 hourly Intra Venous — -
Neonatal Dosage
50 mg/kg (50 (50)) 8 hourly Intramuscular —
50 mg/kg (50 (50)) 8 hourly Intravenous —
Drug Interactions
No data regarding the interactions of Ceftizoxime (Na) was found.
Storage
Inj Store Below 40°C. Protect from Sunlight.
Available Brands in Pakistan
6 active brands listed alphabetically.
CEFIZOX
ActiveBARRETT HODGSON PAKISTAN (PVT) LTD.
DML: CEFIZOX
Inj
CEFTIZ
ActiveSHAIGAN PHARMACEUTICALS (PVT) LTD.
DML: CEFTIZ
Inj
CEFTROL
ActiveMASS PHARMA (PRIVATE) LIMITED
DML: CEFTROL
Inj
SYDOCEF
ActiveSAYDON PHARMACEUTICAL INDUSTRIES (PVT) LTD.
DML: SYDOCEF
Inj
ZOXCEF
ActiveLOWITT PHARMACEUTICALS (PVT) LTD
DML: ZOXCEF
Inj
ZOXI
ActiveLINZ PHARMACEUTICALS (PVT) LTD.
DML: ZOXI
Inj
For educational purposes only. Check current guidelines and consult a qualified healthcare professional before making clinical decisions.