This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Cephazolin is a first-generation cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporanic acid and are closely related to penicillin in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cephazolin is effective in a large variety of bacterial infections, such as respiratory tract, skin and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cephazolin (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Indications
Cephazolin (Na) is primarily indicated in conditions like Bacterial infections, Bone and joint infection, Endocarditis, Genitourinary tract infections, Peritonitis, Persistent neutropenia in advanced HIV infection, Respiratory tract infections, Septicemia, Skin infections, Soft tissue infections, and can also be given in adjunctive therapy as an alternative drug of choice in Biliary tract disorders, Bronchiectasis, Bronchogenic carcinoma, Pneumonia.
Contraindications
Cephazolin (Na) is contraindicated in conditions like Pregnancy,Hypersensitivity to any component of product.
Side Effects
The severe or irreversible adverse effects of Cephazolin (Na), which give rise to further complications include Convulsions, Thrombocytopenia, Hypersensitivity reactions, Eosinophilia, Leucopenia, Neutropenia. Cephazolin (Na) produces potentially life-threatening effects which include Pseudomembranous colitis, Anaphylactic reactions. which are responsible for the discontinuation of Cephazolin (Na) therapy.The symptomatic adverse reactions produced by Cephazolin (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Anorexia, Diarrhea, Genital and anal pruritus, Genital moniliasis, Transient rise in SGPT & SGOT, Rise in blood urea levels.
Warnings
Cephazolin should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma).
High Risk Groups
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
500 to 1000 mg (750 (750)) 6 hourly IV,IM —
Child Dosage
25 to 50 mg/kg (38 (37.5)) 8 hourly Intra Muscular — Maximum of 100mg/kg.
25 to 50 mg/kg (38 (37.5)) 8 hourly Intra Venous — Maximum of 100mg/kg.
Neonatal Dosage
( ) — Not recommended in this age group
Drug Interactions
Cephazolin (Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholPivmecillinam (HCl)Simultaneous administration of other Cephazolin (Na) with Pivmecillinam (HCl) Tablets may produce a synergistic effect.Probenecid These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
