Medicines/Generics/Cephradine

Cephradine

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Cephradine is a first generation, semisynthetic analogue of natural cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporanic acid and are closely related to penicillin in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cephradine is effective against gram positive and gram negative bacteria. Administered orally or by intramuscularly or by intravenous injection. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cephradine is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

Indications

Cephradine is primarily indicated in conditions like Bone and joint infection, Genitourinary tract infections, Lower respiratory tract infections, Pharyngitis, Pneumonia, Prostatitis, Respiratory tract infections, Skin infections, Soft tissue infections, Surgical prophylaxis, Tonsillitis, Upper respiratory tract infections, and can also be given in adjunctive therapy as an alternative drug of choice in Bacterial infections.

Contraindications

Cephradine is contraindicated in conditions like Hypersensitivity.

Side Effects

The severe or irreversible adverse effects of Cephradine, which give rise to further complications include Pseudomembranous colitis, Hypersensitivity reactions, Seizures, Superinfection.Cephradine produces potentially life-threatening effects which include Thrombophlebitis, Anaphylactic reactions. which are responsible for the discontinuation of Cephradine therapy.The signs and symptoms that are produced after the acute over dosage of Cephradine include Nausea, Convulsions, Severe diarrhea. The symptomatic adverse reactions produced by Cephradine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Diarrhea, Skin rashes, Vaginitis, Local pain.

Warnings

Cephradine should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

1 to 2 g (1.5 (1.5)) As recommended. IM — 2 to 4 mg (3 (3)) 6 hourly IV — 250 to 500 mg (380 (375)) 12 hourly PO — Maximum dose: 4 g/day. Frequency may be increased to 3 times if needed.

Child Dosage

25 to 50 mg/kg (38 (37.5)) As recommended. PO — Given in 2-4 divided doses 50 to 100 mg/kg (75 (75)) As recommended. IV/IM — For Paeds of All Ages . given in 4 divided doses .This dose is for severe infections.(to maximum of 75 to 100 mg/kg (88 (87.5)) 24 hourly P/O — Otilis media

Neonatal Dosage

6.3 to 12.5 mg/kg (9.4 (9.4)) 6 hourly oral —

Drug Interactions

Cephradine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementEthacrynic AcidFrusemide or FurosemideConcomitant administeration leads to nephrotoxicityGentamicinNetilmicin (Sulphate)Pivmecillinam (HCl)Simultaneous administration of other Cephradine with Pivmecillinam (HCl) Tablets may produce a synergistic effect.ProbenecidProtamine (Sulphate)Protamine sulfate has been shown to be incompatible with Cephradine.Tobramycin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Storage

Inj Store Below 40°C. Protect from Sunlight. Syrup, Caps Store in a well closed container, at room temperature, Below 30°C. Protect from Sunlight and Moisture.

Available Brands in Pakistan

75 active brands listed alphabetically.

Cephradine

Available Brands in Pakistan

ABIDINE

ADA-CEF

AG-CEPH

AKSOSEF

ALOSEF

ANASEF

ANTIMIC

ARAXIN

AVADINE

BACTOCEF

BECTOCEF

BIOCEF

BIODINE

CARADINE

CARAPIME

CARREL-C

CAYDINE

C-CEPHRA

CEFATIL

CEFCARE

CEFHEIM

CEFMOR

CEFRADIN

CEFRAMED

CEFRAMED FORTE

CEFRESH

CEFROL

CEFTOP

CEPADIN

CEPH-1

CEPHAGRAY

CEPHAXIN

CEPHCEF

CEPHGEN-1

CEPHRADINE

CEPHRADINE BP

CEPHRIDE

CEPHRIL

CEPSAFE

CHROCEF

DARPHIN

DOSEF

DYNACEF

ELDINE

ENCEPH

EPHASEF

EROCEF

FEBCOTIN

FLOSEF

FOSTRUM

GENACEF

GEOSEF

GLIFDIN

GOODCEF

HANCEF

HEALCEF

HICEF

INFEXIN

IPRACEPH

JAFZEN

KAFNASE

KAYSEF

KEFRIL

KEMYCEPH

KOMBAT

LECEPH

LIBROCEF

LOWCEF

QUIN-SAFE

SO-CEPH

SURESEF

T-SEF

VELOSEF

VG-DIN

V-SEF