Chloral Hydrate

Chloral Hydrate is a trichlorinated derivative of acetaldehyde that is converted to trichloroethanol in the body. A hypnotic and is used as a sleeping aid to improve sleep disturbances. It has also been used in the treatment of eclampsia and tetanus.

Chloral Hydrate is primarily indicated in conditions like Insomnia, Postoperative sedation, Pre-operative sedation, and can also be given in adjunctive therapy as an alternative drug of choice in Nausea, vertigo, labyrinthine disorders.

Chloral Hydrate is contraindicated in conditions like Renal failure,Gastritis,Hepatic failure,Cardiac disease,Porphyria.

The severe or irreversible adverse effects of Chloral Hydrate, which give rise to further complications include Bradycardia, Eosinophilia, Eosinophilia, Liver cirrhosis, CNS depression, Hypoprothorombinemia, Hepatic encephalopathy exacerbation.Chloral Hydrate produces potentially life-threatening effects which include Hepatic coma, Drowsiness, Semicoma. which are responsible for the discontinuation of Chloral Hydrate therapy.The signs and symptoms that are produced after the acute over dosage of Chloral Hydrate include Cardiac arrhythmias, Coma, Respiratory depression, Ataxia, Lethargy.The symptomatic adverse reactions produced by Chloral Hydrate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Ataxia, Confusion, Pain, Skin Rash, Hallucination, Gastric irritation, Hypersensitivity, Disorientation, Nightmares, Confusion, Ataxia.

Patients should observe caution while driving or performing other tasks requiring alertness, because it may cause drowsiness. Do not use chloral hydrate in larger doses in patients with severe cardiac disease. Exercise caution in administering to patients prone to addiction. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because may produced allergic reaction (including bronchial asthma).

Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

500 to 1000 mg (750 (750)) 24 hourly PO — Usually taken 30 min before bed time

0.5 to 1 g (0.75 (0.75)) 8 hourly Oral — 12 year to 18 year up to 100mg/kg maximum of 3 g may be used with respiratiry monitrng. 30 to 50 mg/kg (40 (40)) 8 hourly Oral — 1 month to 12 year maximum single dose of 1g

30 to 50 mg/kg (40 (40)) 8 hourly oral — up to 100mg/kg maximum of 3 g may be used with respiratiry monitrng.

No data regarding the interactions of Chloral Hydrate was found.

Suppositories, Caps Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture. Syrup Store in a well closed container, at room temperature. Do not Freeze. Protect from Sunlight.