Chlorambucil

Chlorambucil is an anti-cancer chemotherapy drug used for treatment of Hodgkin's disease and specific types of leukemias and lymphomas. It is from a group of medicines called alkylating agents which acts on cancer cells to slow down or stop their growth. It is a tablet that you swallow with a glass of water.

Chlorambucil is an anti-cancer chemotherapy drug used for treatment of Hodgkin's disease and specific types of leukemias and lymphomas. It is from a group of medicines called alkylating agents which acts on cancer cells to slow down or stop their growth. It is a tablet that you swallow with a glass of water.

You should not take chlorambucil if: You are allergic to chlorambucil or any of the inactive ingredients in the product. See below for product ingredients. You have used chlorambucil in the past and it was not effective. You should tell your doctor if you have had an allergic reaction to another cancer drug such as bendamustine , busulfan, carmustine, dacarbazine, ifosfamide, lomustine, mechlorethamine, melphalan, streptozocin, or temozolomide .  If you have had an allergic reaction to one of these drugs, it may increase your risk of having an allergic reaction to chlorambucil. Tell your doctor if you have ever had: kidney disease, liver disease, a seizure, a head injury or brain tumor , if you have received radiation or chemotherapy within the past 4 weeks.

What are the serious (bad) side effects of chlorambucil? Allergic Reactions: You should immediately get emergency medical help if you have signs of: allergic reaction (difficulty breathing, swelling in your face or throat, hives ) or a severe skin reaction (fever, sore throat , burning eyes, skin pain, red or purple skin rash with blistering and peeling). Other serious (bad) side effects: You should call your doctor at once if you have: a seizure any unusual lump or mass, severe diarrhea or vomiting, a cough that is new or worsening, signs of bone marrow suppression eg. dizziness , feeling tired or short of breath, pale lips or fingernail beds, fast heart rate , signs of liver problems eg. low appetite,  pain in the upper right side of stomach, dark urine, clay-colored stools,  yellowing of the skin or eyes, or signs of low blood cell counts eg. high body temperature, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath. What are the common side effects of chlorambucil? nausea, vomiting or diarrhea, white patches or sores in or around your mouth, bone marrow suppression, low blood cell counts, missed menstrual periods in women. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Chlorambucil may: Decrease blood cells in bone marrow, so it is important you have tests done regularly to check if your blood cells are being affected by this medicine. Increase your risk of bleeding or infection, you should call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, weakness). Increase the chance of developing other cancers. Affect your fertility, which is your ability to become pregnant or be able to father a child. Women should not become pregnant while taking chlorambucil and for a time afterwards as it may harm your fetus or cause birth defects. See below on this page for more information about chlorambucil and pregnancy. You should not breastfeed while using this medicine. See the breastfeeding section below for more information on chlorambucil and breastfeeding.

Chlorambucil may: Decrease blood cells in bone marrow, so it is important you have tests done regularly to check if your blood cells are being affected by this medicine. Increase your risk of bleeding or infection, you should call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, weakness). Increase the chance of developing other cancers. Affect your fertility, which is your ability to become pregnant or be able to father a child. Women should not become pregnant while taking chlorambucil and for a time afterwards as it may harm your fetus or cause birth defects. See below on this page for more information about chlorambucil and pregnancy. You should not breastfeed while using this medicine. See the breastfeeding section below for more information on chlorambucil and breastfeeding.

0.057 to 0.142 mg/kg (0.1 (0.0995)) 24 hourly PO — For 3-6 Weeks, As Required Scraped Dose — Chlorambucil is a tablet that is usually taken daily for 3 to 6 weeks according to your doctor's treatment plan. Sometimes alternate treatment schedules are used which can be intermittent, biweekly or once a month pulse treatments. While on this medicine you must be under the care of a doctor.  You should follow the directions of your doctor and take the medicine exactly as prescribed. Remember to store your tablets in the refrigerator.

0.1 to 0.2 mg/kg (0.15 (0.15)) 24 hourly Oral — -

No indication for use in neonates ( ) —

Other drugs may affect chlorambucil, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using. To check for interactions with chlorambucil, click the link below.

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