Chlorprothixene
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Chlorprothixene is a thioxanthene drug having sedative, antiemetic, antihistaminic, anticholinergic and alpha-adrenergic blocking activity. Chlorprothixene is administered orally or by intramuscular injection.
Indications
Chlorprothixene is primarily indicated in conditions like Agitation, Mania, Psychosis, Schizophrenia, and can also be given in adjunctive therapy as an alternative drug of choice in Anxiety, Herpetic neuralgia.
Contraindications
Chlorprothixene is contraindicated in conditions like Circulatory collapse,Coma.
Side Effects
The severe or irreversible adverse effects of Chlorprothixene, which give rise to further complications include Tardive dyskinesia, Seizures, Systemic lupus erythematosus. Chlorprothixene produces potentially life-threatening effects which include Obstructive Jaundice, Neuroleptic Malignant Syndrome, which are responsible for the discontinuation of Chlorprothixene therapy.The signs and symptoms that are produced after the acute over dosage of Chlorprothixene include Hypotension, Tachycardia, Cardiac arrhythmias, Seizures, Cardio depression, Respiratory arrest, Reduced peristalsis of GIT, Acute oliguria. The symptomatic adverse reactions produced by Chlorprothixene are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin rashes, Sedation, Parkinsonism, Akathisia, Hypotension, Nausea and vomiting, Acute dystonia, Induction of hostility, Extra pyramidal symptoms.
Warnings
Chlorprothixene should be used with caution in patients exposed to extreme heat or phosphorus insecticides, patients in state of alcohol withdrawal, patients with history of peptic ulcer, allergic reactions, with renal impairment, prostatic hypertrophy. Photosensitization may occur, caution patients to take appropriate measure (e.g. wear protective clothing or sunscreen) against exposure to sunlight or UV light. Discontinue use at least 48 hours before myelography.
High Risk Groups
Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
0.23 to 2.88 mg/kg (1.6 (1.555)) 8 hourly PO — -
0.357 to 0.428 mg/kg (0.39 (0.3925)) 8 hourly IM — -
0.357 to 0.428 mg/kg (0.39 (0.3925)) 8 hourly IV — -
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
0.5 to 1 mg/kg (0.75 (0.75)) 24 hourly usaual single dose to a total of 100mg/day (over age 6}. —
Drug Interactions
No data regarding the interactions of Chlorprothixene was found.
Storage
Tab Store in a well closed container, Below 40°C. Do not Freeze. Protect from Sunlight and Moisture.
Available Brands in Pakistan
No brands are recorded for this generic.