Cimetidine (HCl)
Generic medicine reference
Overview
Lumoxiti is an injection used to treat hairy cell leukemia.
Lumoxiti is used in adult patients with hairy cell leukemia that has relapsed.
Lumoxiti is also used if the patient has not responded to previous treatments, and has received at least 2 other treatments, including a type of medicine called purine nucleoside analog (PNA).
It is not known if Lumoxiti is safe and effective in children.
Indications
Lumoxiti is an injection used to treat hairy cell leukemia.
Lumoxiti is used in adult patients with hairy cell leukemia that has relapsed.
Lumoxiti is also used if the patient has not responded to previous treatments, and has received at least 2 other treatments, including a type of medicine called purine nucleoside analog (PNA).
It is not known if Lumoxiti is safe and effective in children.
Contraindications
To make sure Lumoxiti is safe for you, tell your doctor if you have ever had:
kidney disease; or a condition that affects your blood and blood vessels (such as hemolytic uremic syndrome or severe thrombotic microangiopathy).
You may need to have a negative pregnancy test before starting this treatment.
Do not use Lumoxiti if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 30 days after your last dose. Tell your doctor right away if you become pregnant.
You should not breastfeed while using Lumoxiti.
Side Effects
Get emergency medical help if you have signs of an allergic reaction to Lumoxiti: hives ; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your caregiver if you feel dizzy, nauseated, hot or cold, light-headed, or have a headache , muscle pain, cough, trouble breathing, or fast heartbeats.
Lumoxiti can damage red blood cells, which may cause irreversible kidney failure . Get emergency medical help if you have: unusual bruising or bleeding, fever, confusion, tiredness or irritability, stomach pain, vomiting, dark urine, fast heartbeats, and little or no urination.
Call your doctor at once if you have:
low red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; signs of an electrolyte imbalance - muscle spasms or contractions, numbness or tingly feeling, nausea , fast or irregular heartbeats, seizure; or capillary leak syndrome - dizziness, weakness, cough, trouble breathing, and sudden swelling or weight gain.
Serious side effects may be more likely in older adults.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common Lumoxiti side effects may include:
swelling in your arms, legs, or face; nausea, diarrhea , constipation ; headache, tiredness; fever; or anemia.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
Call your doctor right away if you have signs of a rare but serious condition called capillary leak syndrome: dizziness , weakness, cough, trouble breathing, and sudden swelling or weight gain.
Lumoxiti can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.
Moxetumomab pasudotox can damage your kidneys, especially if you already have kidney disease or if you are 65 years of age or older. Get emergency medical help if you have: unusual bruising or bleeding, fever, confusion, tiredness or irritability, stomach pain, vomiting , dark urine, fast heartbeats, and little or no urination.
High Risk Groups
Call your doctor right away if you have signs of a rare but serious condition called capillary leak syndrome: dizziness , weakness, cough, trouble breathing, and sudden swelling or weight gain.
Lumoxiti can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.
Moxetumomab pasudotox can damage your kidneys, especially if you already have kidney disease or if you are 65 years of age or older. Get emergency medical help if you have: unusual bruising or bleeding, fever, confusion, tiredness or irritability, stomach pain, vomiting , dark urine, fast heartbeats, and little or no urination.
Adult Dosage
400 mg (400 (400)) 12 hourly PO — For 6 weeks.
Child Dosage
25 to 30 mg/kg (28 (27.5)) As recommended. Oral — in divided doses
Neonatal Dosage
20 mg/kg (20 (20)) As recommended. oral — in divided doses
Drug Interactions
Other drugs may interact with moxetumomab pasudotox, including prescription and over-the-counter medicines, vitamins , and herbal products . Tell your doctor about all your current medicines and any medicine you start or stop using.
Storage
Inj Store at room temperature. Do not Freeze. Protect from Sunlight. Tab, Susp Store in a well closed container, at room temperature. Protect from Sunlight.
Available Brands in Pakistan
7 active brands listed alphabetically.
CIMET
ActiveFEROZSONS LABORATOIES LTD.
DML: CIMET
TabsSusp
MEDI CIM
ActiveMAC & RANS PHARMACEUTICALS (PVT) LTD
DML: MEDI CIM
Susp
NORMACID
ActiveWILSONS PHARMACEUTICALS
DML: NORMACID
TabsSusp
PEPTIMAX
ActiveFOZAN PHARMACEUTICALS INDUSTRIERS (PVT) LTD
DML: PEPTIMAX
Susp
TAGAMET
ActiveGLAXOSMITHKLINE
DML: TAGAMET
InjTabs
T-DINE
ActiveGABA PHARMACEUTICALS LABS
DML: T-DINE
Tabs
UL-GET
ActiveSAYDON PHARMACEUTICAL INDUSTRIES (PVT) LTD.
DML: UL-GET
InjTabs
For educational purposes only. Check current guidelines and consult a qualified healthcare professional before making clinical decisions.