Medicines/Generics/Citicoline

Citicoline

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Supplementation with citicoline increases choline stores available for other biosynthetic pathways. Citicoline appears to decrease glutamate levels in the brain and increase adenosine triphosphate, which in turn offers protection against ischemic neurotoxicity. Increased glucose metabolism in the brain and cerebral blood flow has also been demonstrated, as well as increased availability of the neurotransmitters acetylcholine, norepinephrine, and dopamine.( Arenth 2011 , Secades 2006 )

Indications

Contraindications

Citicoline is contraindicated in conditions like Unconsciousness, Pregnancy, Brain surgery, Breast feeding.

Side Effects

The severe or irreversible adverse effects of Citicoline, which give rise to further complications include Hypotension. The symptomatic adverse reactions produced by Citicoline are more or less tolerable and if they become severe, they can be treated symptomatically, these include Excitement, Insomnia, Stomach pain, Diarrhea.

Warnings

For patients with acute, severe and progressive disturbances of consciousness due to head injury and brain surgery, Citicoline injection should be administered in conjunction with hemostatics and intracranial pressure relieving drugs, or treatment such as hypothermia.

High Risk Groups

Drug should not be given to Pregnant Mothers. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

1 g (1 (1)) 24 hourly IV — For 4 weeks. 200 to 600 mg (400 (400)) As recommended. PO — Total dose can be given as 2 divided doses. For 6 weeks.

Child Dosage

( ) — Not recommended in this age group

Neonatal Dosage

( ) — Not recommended in this age group

Drug Interactions

None well documented.

Storage

Inj, syrups Store in a well closed container, . Protect from Sunlight, Moisture and Heat.