Clodronate
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Clodronate used as an adjunct in the treatment of severe hypercalcaemia associated with malignancy.
Indications
Clodronate is primarily indicated in conditions like Hypercalcemia due to malignancy, Osteolytic bone metastases, Paget's disease.
Contraindications
Clodronate is contraindicated in conditions like Hypersensitivity,Renal insufficiency.
Side Effects
The severe or irreversible adverse effects of Clodronate, which give rise to further complications include Secondary hyperparathyroidism. Clodronate produces potentially life-threatening effects which include Acute Renal Failure. which are responsible for the discontinuation of Clodronate therapy .The signs and symptoms that are produced after the acute over dosage of Clodronate include Acute renal failure, Hypoglycemia. The symptomatic adverse reactions produced by Clodronate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, GI upset, Hypocalcemia.
Warnings
NSAIDs should not be used concurrently with OSPHOS. Concurrent use of NSAIDs with OSPHOS may increase the risk of renal toxicity and acute renal failure.
Human Warnings: Not for human use. Keep this and all drugs out of the reach of children. Consult a physician in case of accidental human exposure.
High Risk Groups
NSAIDs should not be used concurrently with OSPHOS. Concurrent use of NSAIDs with OSPHOS may increase the risk of renal toxicity and acute renal failure.
Human Warnings: Not for human use. Keep this and all drugs out of the reach of children. Consult a physician in case of accidental human exposure.
Adult Dosage
0.035 mg/kg.min (0.035 (0.035)) 24 hourly IV Inf — For 2 Hours per day, for not >10 days
22.857 to 45.714 mg/kg (34 (34.2855)) 24 hourly PO — For max of 6 Months
Scraped Dose — Clinical improvement is most evident at 2 months post-treatment (see EFFECTIVENESS ). Of the horses that responded to treatment with OSPHOS in the field study, 65% maintained their level of improvement through the 6 month evaluation.
If there is no response to initial therapy, the horse should be re-evaluated. For horses that initially respond to OSPHOS but do not maintain their clinical improvement for 6 months, OSPHOS may be re-administered at 3 to 6 month intervals based on recurrence of clinical signs. For horses that respond to OSPHOS and maintain clinical improvement for 6 months, OSPHOS should be re-administered after clinical signs recur.
Child Dosage
Safety not established ( ) —
Neonatal Dosage
( ) — Not recommended in this age group
Drug Interactions
No data regarding the interactions of Clodronate was found.
Storage
No storage information is recorded for this medicine yet.
Available Brands in Pakistan
No brands are recorded for this generic.