Clofazimine

Clofazimine is used together with other medicines to treat a form of leprosy (also known as Hansen's disease), called lepromatous leprosy, including dapsone-resistant lepromatous leprosy, and lepromatous leprosy complicated by erythema nodosum leprosum. Lepromatous leprosy is a more severe and contagious form of the disease, has widespread skin bumps and rashes (multibacillary leprosy), numbness, and muscle weakness, and may also affect body organs (eg, nose, kidneys, male reproductive organs). This medicine is available only with your doctor's prescription.

Clofazimine is used together with other medicines to treat a form of leprosy (also known as Hansen's disease), called lepromatous leprosy, including dapsone-resistant lepromatous leprosy, and lepromatous leprosy complicated by erythema nodosum leprosum. Lepromatous leprosy is a more severe and contagious form of the disease, has widespread skin bumps and rashes (multibacillary leprosy), numbness, and muscle weakness, and may also affect body organs (eg, nose, kidneys, male reproductive organs). This medicine is available only with your doctor's prescription.

Clofazimine is contraindicated in conditions like Diarrhea, Peptic ulcer, Vomiting, .

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Constipation diarrhea heartburn indigestion loss of appetite nausea pain or discomfort in the chest, upper stomach, or throat stomach pain vomiting Less common Blurry vision dry mouth dryness, burning, itching, or irritation of the eye flushed, dry skin fruit-like breath odor increased hunger increased thirst increased urination sweating troubled breathing unexplained weight loss unusual tiredness or weakness Rare Bloody or black, tarry stools bloody or cloudy urine bone pain chest pain chills constipation cough dark urine decreased urine decreased vision depression and thoughts of suicide secondary to skin discoloration difficult, burning, or painful urination fever frequent urge to urinate general tiredness and weakness irregular heartbeat light-colored stools mood changes muscle pain or cramps nerve pain numbness or tingling in the hands, feet, or lips pain in the chest, groin, or legs, especially the calves pain spreading to the left shoulder pale skin seizures severe stomach pain severe, sudden headache slurred speech sore throat sores, ulcers, or white spots on the lips or in the mouth stomach cramping sudden loss of coordination sudden, severe weakness or numbness in the arm or leg swelling swollen, painful, or tender lymph glands in the neck, armpit, or groin troubled breathing with exertion unusual bleeding or bruising upper right abdominal pain and fullness vision changes vomiting of blood or material that looks like coffee grounds yellow eyes and skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Dry, rough, or scaly skin pink to brownish black skin discoloration Less common Discoloration of the eye, urine, stool, spit, sweat itching, skin rash Rare Bad unusual or unpleasant (after)taste change in taste dizziness drowsiness giddiness Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Clofazimine should be used with caution in patients with any pre-existing stomach disorders or any allergy. It should be used with caution when driving or operating machinery because it may cause dizziness. This medication should be used only if clearly needed during pregnancy or lactation.

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

1.428 mg/kg (1.4 (1.428)) 24 hourly PO — -

4.166 mg/kg (4.2 (4.166)) As recommended. Oral — Initially on alternate days 8.333 mg/kg (8.3 (8.333)) As recommended. Oral — Maintenance per month

12.5 mg/kg (12 (12.5)) As recommended. oral — maintenance, monthly 6.25 mg/kg (6.2 (6.25)) 12 hourly oral — Initial, weekly

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Bepridil Cisapride Dronedarone Levoketoconazole Mesoridazine Pimozide Piperaquine Saquinavir Sparfloxacin Terfenadine Thioridazine Ziprasidone Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Adagrasib Alfuzosin Amiodarone Amisulpride Amitriptyline Anagrelide Apomorphine Aprepitant Aripiprazole Aripiprazole Lauroxil Arsenic Trioxide Asenapine Astemizole Atazanavir Azithromycin Bedaquiline Bosutinib Buprenorphine Buserelin Chloroquine Chlorpromazine Ciprofloxacin Citalopram Clarithromycin Clomipramine Clothiapine Clozapine Colchicine Crizotinib Cyclobenzaprine Dabrafenib Daridorexant Dasatinib Degarelix Delamanid Desipramine Deslorelin Deutetrabenazine Dexmedetomidine Disopyramide Dofetilide Dolasetron Domperidone Donepezil Doxepin Droperidol Ebastine Efavirenz Elexacaftor Encorafenib Entrectinib Eribulin Erythromycin Escitalopram Etrasimod Famotidine Felbamate Fexinidazole Fingolimod Flecainide Fluconazole Fluoxetine Formoterol Fosaprepitant Foscarnet Fosphenytoin Fostemsavir Galantamine Gatifloxacin Gemifloxacin Gepirone Gonadorelin Goserelin Granisetron Halofantrine Haloperidol Histrelin Hydroquinidine Hydroxychloroquine Hydroxyzine Ibutilide Iloperidone Imipramine Itraconazole Ivabradine Ivacaftor Ivosidenib Ketoconazole Lapatinib Lefamulin Lenvatinib Leuprolide Levofloxacin Lumefantrine Lurbinectedin Macimorelin Mavacamten Mefloquine Methadone Methotrimeprazine Metronidazole Mifepristone Mirtazapine Mizolastine Mobocertinib Moricizine Moxifloxacin Nafarelin Nelfinavir Nilotinib Norfloxacin Octreotide Ofloxacin Olanzapine Ondansetron Osilodrostat Osimertinib Oxaliplatin Ozanimod Pacritinib Paliperidone Palovarotene Panobinostat Papaverine Paroxetine Pasireotide Pazopanib Pentamidine Perphenazine Phenobarbital Phenytoin Pimavanserin Pipamperone Pitolisant Ponesimod Posaconazole Pralsetinib Primidone Probucol Procainamide Prochlorperazine Promethazine Propafenone Protriptyline Quetiapine Quinidine Quinine Quizartinib Ranolazine Relugolix Ribociclib Risperidone Ritonavir Selpercatinib Sertindole Sertraline Sevoflurane Siponimod Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Solifenacin Sorafenib Sotalol Sulpiride Sultopride Sunitinib Tacrolimus Tamoxifen Telaprevir Telavancin Telithromycin Tetrabenazine Tezacaftor Tolterodine Toremifene Trazodone Triclabendazole Trimipramine Triptorelin Vandetanib Vardenafil Vemurafenib Venlafaxine Vilanterol Vinflunine Voclosporin Voriconazole Vorinostat Zolpidem Zotepine Zuclopenthixol Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aluminum Hydroxide Amlodipine Magnesium Hydroxide

Caps Store in a well closed container, at room temperature, Between 15°C-30°C. Protect from Sunlight, Moisture and Heat.