Crisantaspase

Erwinaze ( asparaginase Erwinia chrysanthemi ) is used to treat acute lymphoblastic leukemia (ALL) in patients who have developed hypersensitivity to E. coli-derived asparaginase. Erwinaze is a cancer medication that interferes with the growth and spread of cancer cells. Erwinaze works by lowering the levels of asparagine in your body, a substance the cancer cells need to survive. Erwinaze is given as an intravenous infusion or intramuscular injection and is often given as part of a multi-agent chemotherapeutic regimen.

Erwinaze ( asparaginase Erwinia chrysanthemi ) is used to treat acute lymphoblastic leukemia (ALL) in patients who have developed hypersensitivity to E. coli-derived asparaginase. Erwinaze is a cancer medication that interferes with the growth and spread of cancer cells. Erwinaze works by lowering the levels of asparagine in your body, a substance the cancer cells need to survive. Erwinaze is given as an intravenous infusion or intramuscular injection and is often given as part of a multi-agent chemotherapeutic regimen.

Erwinaze should not be used in patients with a history of: Serious hypersensitivity reactions to Erwinaze, including anaphylaxis Serious pancreatitis with prior L-asparaginase therapy Serious thrombosis with prior L-asparaginase therapy Serious hemorrhagic events with prior L-asparaginase therapy

The severe or irreversible adverse effects of Crisantaspase, which give rise to further complications include Hepatotoxicity, Coma, Hemorrhage, Thrombosis, Stupor, Tremors, Hyperplasia, Hemorrhagic pancreatitis. Crisantaspase produces potentially life-threatening effects which include Hypotension, Bronchospasm, Anaphylaxis, Laryngeal edema, Urticaria. which are responsible for the discontinuation of Crisantaspase therapy. The symptomatic adverse reactions produced by Crisantaspase are more or less tolerable and if they become severe, they can be treated symptomatically, these include Abdominal distension, Drowsiness, Fatigue, Nausea, Vomiting, Fever, Abdominal pain, Confusion, Hyperglycemia, Increased serum bilirubin, Increased cholesterol, Hepatomegaly, Malabsorption, Confusion.

Some people develop a life-threatening allergic reaction to Erwinaze. You will need to receive Erwinaze in a hospital or clinic setting to quickly treat any serious side effects that may occur. Get emergency medical help if you have any signs of an allergic reaction to Erwinaze: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have serious side effects such as severe pain in your upper stomach, nausea, and vomiting, easy bruising or bleeding, increased thirst or urination, sudden numbness or severe headache, warmth or swelling in your legs, or sudden problems with your vision, speech, or balance. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies , and all medicines you use.

Some people develop a life-threatening allergic reaction to Erwinaze. You will need to receive Erwinaze in a hospital or clinic setting to quickly treat any serious side effects that may occur. Get emergency medical help if you have any signs of an allergic reaction to Erwinaze: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have serious side effects such as severe pain in your upper stomach, nausea, and vomiting, easy bruising or bleeding, increased thirst or urination, sudden numbness or severe headache, warmth or swelling in your legs, or sudden problems with your vision, speech, or balance. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies , and all medicines you use.

20 IU/m2 (20 (20)) As recommended. IV — 4.8hourly

100 (100 (100)) As recommended. I/V — daily for 10 days after treatment with vincristine and prednisone 600 units/kg (600 (600)) As recommended. I/M —

No neonatal dosage information is recorded for this medicine yet.

Other drugs may interact with asparaginase Erwinia chrysanthemi, including prescription and over-the-counter medicines, vitamins , and herbal products . Tell your doctor about all other medicines you use.

Inj (reconstituted soln) Store at room temperature. Use within 15 min if kept at room temperature. Powder for Inj Store in refrigerator.