Cyclizine

Cyclizine is an H1 antihistaminic agent. Cyclizine is used as an antiemetic. Chemically Cyclizine is 1-(diphenylmethyl)-4-methylpiperazine. Cyclizine is effective to prevent or treat nausea, vomiting and dizziness caused by motion sickness. Cyclizine is administered intramuscularly.

Cyclizine is primarily indicated in conditions like Motion sickness, Nausea and vomiting, Nausea and vomiting (chemotherapy induced), Nausea and vomiting (palliative care), Vertigo, Vestibular disturbances, and can also be given in adjunctive therapy as an alternative drug of choice in Meniere's disease.

Cyclizine

The severe or irreversible adverse effects of Cyclizine, which give rise to further complications include Tardive dyskinesia, Neurologic effects. Cyclizine produces potentially life-threatening effects which include Neuroleptic Malignant Syndrome, Neuroleptic malignant syndrome. which are responsible for the discontinuation of Cyclizine therapy. The symptomatic adverse reactions produced by Cyclizine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Restlessness, Tachycardia, Constipation, Insomnia, Nervousness, Blurred vision, Urinary retention, Urticaria, Dryness of mouth, Visual hallucinations.

Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness. Cyclizine should be used with caution in patients with asthma, glaucoma, obstructive disease of gastrointestinal (GI) tract.

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

50 mg (50 (50)) 8 hourly PO,IV,IM —

2.5 mg/kg (2.5 (2.5)) As recommended. Oral — As Required

Not rcommended in this age goup ( ) —

Cyclizine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholDiamorphine (HCl)Fentanyl (Citrate)Methohexitone (Na)OxycodoneThiopentone (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Inj Store Below 40°C. Do not Freeze. Protect from Sunlight and Moisture. Tab, Syrup Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.