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Medicines/Generics/Cyclobenzaprine hydrochloride

Cyclobenzaprine hydrochloride

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview
Cyclobenzaprine is a prescription muscle relaxant used for muscle spasms caused by sprains and strains, including acute low back or neck pai n. Cyclobenzaprine is used short-term, together with rest and physical therapy, when used to treat skeletal muscle conditions such as pain or injury. Cyclobenzaprine is also used for fibromyalgia to help reduce pain, improve sleep quality, and relieve fatigue. For this condition, it is available as a sublingual tablet under the brand name Tonmya . Tonmya may begin to relieve pain as early as the first week of treatment, with continued improvements in both pain and sleep over time. Cyclobenzaprine works by blocking nerve impulses (or pain sensations) that are sent to your brain. Cyclobenzaprine acts primarily through the brain stem rather than the spinal cord and does not act directly on skeletal muscle, and will not reduce muscle spasms due to central nervous system (CNS) disease, such as cerebral palsy.
Indications
Cyclobenzaprine is a prescription muscle relaxant used for muscle spasms caused by sprains and strains, including acute low back or neck pai n. Cyclobenzaprine is used short-term, together with rest and physical therapy, when used to treat skeletal muscle conditions such as pain or injury. Cyclobenzaprine is also used for fibromyalgia to help reduce pain, improve sleep quality, and relieve fatigue. For this condition, it is available as a sublingual tablet under the brand name Tonmya . Tonmya may begin to relieve pain as early as the first week of treatment, with continued improvements in both pain and sleep over time. Cyclobenzaprine works by blocking nerve impulses (or pain sensations) that are sent to your brain. Cyclobenzaprine acts primarily through the brain stem rather than the spinal cord and does not act directly on skeletal muscle, and will not reduce muscle spasms due to central nervous system (CNS) disease, such as cerebral palsy.
Contraindications
You should not use cyclobenzaprine if you are allergic to it, or if you have: hyperthyroidism; heart block, heart rhythm disorder, congestive heart failure; or if you have recently had a heart attack. The safety and effectiveness of cyclobenzaprine HCl for muscle spasm in patients below 15 years of age have not been established. Cyclobenzaprine for fibromyalgia (Tonmya) is only approved for use in adults. Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Some medicines can interact with cyclobenzaprine and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products , or medicine for depression , mental illness, Parkinson's disease , migraine headaches, serious infections, or prevention of nausea and vomiting . Ask your doctor before making any changes in how or when you take your medications. To make sure cyclobenzaprine is safe for you, tell your doctor if you have: thyroid disease; liver disease; glaucoma ; enlarged prostate ; or problems with urination.
Side Effects
Get emergency medical help if you have signs of an allergic reaction to cyclobenzaprine : hives ; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: fast or irregular heartbeats; chest pain or pressure, pain spreading to your jaw or shoulder; or sudden numbness or weakness (especially on one side of the body), slurred speech, balance problems. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate , muscle stiffness, twitching, loss of coordination, nausea , vomiting, or diarrhea . Serious side effects may be more likely in older adults. Common cyclobenzaprine side effects may include: drowsiness , tiredness ; headache , dizziness ; dry mouth ; or upset stomach , nausea, constipation . This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
You should not use cyclobenzaprine if you have an allergy to the medication, a certain type of thyroid disorder (hyperthyroidism), heart block, congestive heart failure , a heart rhythm disorder, or you have recently had a heart attack . Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid , linezolid , phenelzine , rasagiline , selegiline , or tranylcypromine .
High Risk Groups
You should not use cyclobenzaprine if you have an allergy to the medication, a certain type of thyroid disorder (hyperthyroidism), heart block, congestive heart failure , a heart rhythm disorder, or you have recently had a heart attack . Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid , linezolid , phenelzine , rasagiline , selegiline , or tranylcypromine .
Adult Dosage
( ) — Not recommended in this age group
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Using cyclobenzaprine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures . Tell your doctor about all your other medicines, especially: MAO inhibitors, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine; Any antidepressant or anxiety medications; bupropion ( Zyban , for smoking cessation or Wellbutrin, for depression); meperidine ; tramadol ; verapamil ; cold or allergy medicine that contains an antihistamine (Benadryl and others); medicine to treat Parkinson's disease; medicine to treat excess stomach acid, stomach ulcer , motion sickness , or irritable bowel syndrome ; medicine to treat overactive bladder ; or bronchodilator asthma medication. This list is not complete. Other drugs may interact with cyclobenzaprine, including prescription and over-the-counter medicines, vitamins , and herbal products . Not all possible drug interactions are listed here.
Storage
tablet Store Between 15°C-30°C.