Cyclophosphamide

Cyclophosphamide is used to treat several types of cancer. Oral cyclophosphamide is also used to treat minimal change nephrotic syndrome (kidney disease) in children who cannot use other treatments or when other treatments have failed. Cyclophosphamide may also be used for purposes not listed in this medication guide.

Cyclophosphamide is used to treat several types of cancer. Oral cyclophosphamide is also used to treat minimal change nephrotic syndrome (kidney disease) in children who cannot use other treatments or when other treatments have failed. Cyclophosphamide may also be used for purposes not listed in this medication guide.

You should not use cyclophosphamide if you are allergic to cyclophosphamide or similar medicines, or if you have: a bladder obstruction. Tell your doctor if you have or have ever had: weak immune system (caused by disease or by using certain medicines); an active or chronic infection (including a bladder infection ); drink alcohol; bladder problems; lung disease; heart disease ; if you are receiving other cancer treatments or radiation; kidney disease (or if you are on dialysis); or liver disease . Using cyclophosphamide may increase your risk of developing other cancers. Ask your doctor about this risk. You may need to have a negative pregnancy test before starting this treatment. May harm an unborn baby. Do not use if you are pregnant. Use effective birth control while using cyclophosphamide and for at least 1 year after your last dose. Tell your doctor if you become pregnant. Men using cyclophosphamide should use condoms during treatment, and for at least 4 months after treatment ends. Cyclophosphamide may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine. Cyclophosphamide may cause you to stop having menstrual periods. Your periods should return to normal within a few months after you stop using cyclophosphamide. However, older women may have early menopause due to this effect. Talk to your doctor about this risk. Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

Get emergency medical help if you have signs of an allergic reaction : hives, difficult breathing, swelling of your face, lips, tongue, or throat. cyclophosphamide can cause serious or fatal side effects, including: unusual bruising or bleeding, new signs of infection (fever, weakness, cough, diarrhea, burning when you urinate); bone marrow suppression; feeling short of breath on exertion; chest discomfort, dry cough or hack; feeling weak or tired, loss of appetite, rapid weight loss ; kidney problems --swelling, urinating less, feeling tired or short of breath, blood in urine; heart problems --swelling, rapid weight gain, feeling short of breath; liver problems --loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); low blood sodium --headache, confusion, problems with thinking or memory, weakness, feeling unsteady; or low blood cell counts --fever, chills, tiredness, blisters or ulcers in your mouth, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath. Common side effects of cyclophosphamide may include: fever, low blood cell counts; mouth sores; nausea, vomiting, diarrhea; hair loss; or missed menstrual periods. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

You should not use cyclophosphamide if you have a bladder obstruction or other urination problems. You may feel faint while using cyclophosphamide. Call your doctor right away if you have fast or pounding heartbeats, chest pain, shortness of breath , and sudden dizziness.

You should not use cyclophosphamide if you have a bladder obstruction or other urination problems. You may feel faint while using cyclophosphamide. Call your doctor right away if you have fast or pounding heartbeats, chest pain, shortness of breath , and sudden dizziness.

2 to 6 mg/ kg (4 (4)) As recommended. PO — In div.doses per week. 2 to 6 mg/kg (4 (4)) As recommended. IV — per week.

1250 to 2330 mg/sq.meter (1800 (1790)) As recommended. Intra Venous — Per Month. 730 mg/sq.meter (1300 (1338)) As recommended. Oral — On Days 1-5 every month

No neonatal dosage information is recorded for this medicine yet.

Many other drugs can be dangerous when used with cyclophosphamide. Tell your doctor if you also use: protease inhibitors such as hiv/aids medications; chemotherapy or radiation; medicine to prevent organ transplant rejection such as cyclosporine ; if you use a blood thinner (such as warfarin) and you have routine "INR" or prothrombin time tests; heart medications; or metronidazole , tamoxifen . Cyclophosphamide can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure , depression , mental illness, cancer, malaria. Cyclophosphamide can harm your liver, especially if you also use certain medicines for infections, birth control, high cholesterol , seizures, pain, or arthritis (including Advil). Cyclophosphamide can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis , organ transplant rejection, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve); This list is not complete and many other drugs may affect cyclophosphamide. This includes prescription and over-the-counter medicines, vitamins, and herbal products . Not all possible drug interactions are listed here.

Inj (reconstituted soln) Store at room temperature or refrigerator. Use within 6 days if refrigerated and within 24 hrs if kept at room temperature. Oral Soln (reconstituted soln) Store in refrigerator. Use within 6 days if kept at room temperature. Tab Store in a well closed container, at room temperature, Below 25°C.