Dacarbazine
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Dacarbazine is used to treat skin cancer ( malignant melanoma ) and Hodgkin's disease .
Dacarbazine may also be used for purposes not listed in this medication guide.
Indications
Dacarbazine is used to treat skin cancer ( malignant melanoma ) and Hodgkin's disease .
Dacarbazine may also be used for purposes not listed in this medication guide.
Contraindications
You should not use dacarbazine if you are allergic to it.
Tell your doctor if you have ever had:
liver disease ; a bleeding or blood clotting disorder; or bone marrow suppression.
It is not known whether dacarbazine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
You should not breastfeed while using dacarbazine.
Side Effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Dacarbazine may cause serious side effects. Call your doctor at once if you have:
low blood cell counts --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or liver problems --loss of appetite, stomach pain (upper right side), tiredness, itching , dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects of dacarbazine may include:
loss of appetite, nausea , vomiting .
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
Dacarbazine can increase your risk of bleeding or infection . Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, weakness, cough, diarrhea , burning when you urinate).
High Risk Groups
Dacarbazine can increase your risk of bleeding or infection . Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, weakness, cough, diarrhea , burning when you urinate).
Adult Dosage
2 to 4.5 mg/kg (3.2 (3.25)) 24 hourly IV — For 10 Days, repeated per month
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Other drugs may affect dacarbazine, including prescription and over-the-counter medicines, vitamins , and herbal products . Tell your doctor about all your current medicines and any medicine you start or stop using.
Storage
Inj (reconstituted soln) Store at room temperature or refrigerator. Protect from Sunlight. Use within 3 days (at4C) if refrigerated and within 8 hrs if kept at room temperature.
Available Brands in Pakistan
2 active brands listed alphabetically.
DAC
ActiveMEDIVET (PVT) LTD.
DML: DAC
Inj
DECARB
ActiveAJM Pharma Pvt Ltd DSL: 262
DML: DECARB
Inj
3 additional records are present but flagged "Unverified / Legacy" and not listed.
