Medicines/Generics/Debrisoquine (Sulphate)

Debrisoquine (Sulphate)

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

Spot an error in this entry? Submit a correction

Overview

Chemically Debrisoquine (Sulphate) is 3, 4-dihydro-2(1H)- . Debrisoquine (Sulphate) is adrenergic neuron-blocking agent. Debrisoquine (Sulphate) is an antihypertensive drug similar to guanethidine.

Indications

Debrisoquine (Sulphate) is primarily indicated in conditions like Hypertension, and can also be given in adjunctive therapy as an alternative drug of choice in Amoebic dysentery, Granulomatous disease, Skin lesions.

Contraindications

Debrisoquine (Sulphate) is contraindicated in conditions like Pheochromocytoma, Renal failure, Documented hypersensitivity.

Side Effects

Debrisoquine (Sulphate) produces potentially life-threatening effects which include Blood pressure reduction, which are responsible for the discontinuation of Debrisoquine (Sulphate) therapy. The signs and symptoms that are produced after the acute over dosage of Debrisoquine (Sulphate) include Orthostatic hypotension. The symptomatic adverse reactions produced by Debrisoquine (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Syncope, Failure of ejaculation.

Warnings

Take this medication as directed by physician. Take no more of the medication than the amount prescribed. Take with food to minimize possible gastrointestinal irritation.

High Risk Groups

Drug should not be given to Pediatrics, patients suffering from Kidney dysfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

0.143 to 0.285 mg/kg (0.21 (0.214)) 24 hourly PO — Initial 0.285 to 1.714 mg/kg (1 (0.9995)) 24 hourly PO — Maintenance

Child Dosage

No child dosage information is recorded for this medicine yet.

Neonatal Dosage

No neonatal dosage information is recorded for this medicine yet.

Drug Interactions

Debrisoquine (Sulphate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholAmitriptyline (HCl)Chlorpromazine (HCl)Desipramine (HCl)Dothiepin (HCl)Doxepin (HCl)Imipramine (HCl)Lofepramine (HCl)Theoretical potential for LOFEPRAMINE reducing the HYPOTENSIVE effect of DEBRISOQUINE. Noradrenaline (Acid Tartrate)Phenylpropanolamine (HCl)Trimipramine (Maleate) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Storage

Tab Store in a well closed container. Protect from Sunlight.