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Medicines/Generics/Deferoxamine

Deferoxamine

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview
Deferoxamine binds to iron and removes it from the bloodstream. Deferoxamine is used to treat acute (immediate) iron overdose. Deferoxamine is also used to treat chronic (long-term) iron overload caused by repeated blood transfusions. Deferoxamine may also be used for purposes not listed in this medication guide.
Indications
Deferoxamine binds to iron and removes it from the bloodstream. Deferoxamine is used to treat acute (immediate) iron overdose. Deferoxamine is also used to treat chronic (long-term) iron overload caused by repeated blood transfusions. Deferoxamine may also be used for purposes not listed in this medication guide.
Contraindications
You should not use deferoxamine if you are allergic to it, or if you have: severe kidney disease; or if you are unable to urinate. Tell your doctor if you have ever had: kidney disease (or if you are on dialysis); heart disease ; liver disease ; vision or hearing problems; asthma or other breathing disorder; low levels of calcium in your blood ( hypocalcemia ); or a parathyroid disorder. If you need to have any type of x-ray or CT scan using a dye that is injected into a vein, you may need to temporarily stop using deferoxamine. Be sure the doctor knows ahead of time that you are using deferoxamine. Tell your doctor if you are pregnant or breast-feeding. Deferoxamine is not approved for use by anyone younger than 3 years old.
Side Effects
Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. Deferoxamine may cause serious side effects. Call your doctor at once if you have: blurred vision, poor night vision, trouble seeing colors, trouble with side (peripheral) vision, seeing halos around lights; eye pain, or a cloudy appearance in the eye; pain behind your eyes; ringing in your ears, hearing problems; a light-headed feeling, like you might pass out; little or no urination; shortness of breath or rapid breathing; fever; severe, watery, bloody diarrhea with cramping; flushing (sudden warmth, redness, or tingly feeling); stuffy nose, fever, redness or swelling around your nose and eyes, scabbing inside your nose; muscle weakness, bone pain; seizure; o confusion, problems with speech or memory. Some side effects may be more likely in older adults. Long-term use of deferoxamine can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using deferoxamine. Common side effects of deferoxamine may include: reddish colored urine; muscle spasm ; numbness, tingling, burning pain; unusual bruising or bleeding; nausea, vomiting , diarrhea; dizziness; or pain, burning, swelling, redness, rash, itching , blistering, scarring, or a hard lump where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
You should not use this medicine if you have severe kidney disease, or if you are unable to urinate.
High Risk Groups
You should not use this medicine if you have severe kidney disease, or if you are unable to urinate.
Adult Dosage
15 mg/kg/hr (15 (15)) As recommended. Cont. IV-inf — Max. 80 mg/kg in 24 hrs.
Child Dosage
28.571 mg/kg (29 (28.571)) 24 hourly Intra Muscular — Initial 71.428 mg/kg (71 (71.428)) As recommended. Oral — Maintenance, As Required
Neonatal Dosage
28.571 mg/kg (29 (28.571)) 24 hourly Intra Muscular — Initial 71.428 mg/kg (71 (71.428)) As recommended. Oral — Maintenance, As Required
Drug Interactions
Tell your doctor about all your other medicines, especially: prochlorperazine ( Compazine , Compro ); or a vitamin C supplement. This list is not complete. Other drugs may affect deferoxamine, including prescription and over-the-counter medicines, vitamins , and herbal products . Not all possible drug interactions are listed here.
Storage
Inj Store in a well closed container. Refrigeration is recommended. Protect from Sunlight.