Dehydroemetine (HCl)
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Dehydroemetine (HCl) is a synthetically produced antiprotozoal agent similar to emetine in its anti-amoebic properties and structure (they differ only in a double bond next to the ethyl substituent), but it produces fewer side effects. It is used in the treatment of amebic dysentery (infection of intestinal tract).
Indications
Dehydroemetine (HCl) is primarily indicated in conditions like Amoebic dysentery, Amoebic granulomata, Hepatic amoebiasis, Skin lesions.
Contraindications
Dehydroemetine (HCl) is contraindicated in conditions like Polyneuritis, Heart disease.
Side Effects
Dehydroemetine (HCl) produces potentially life-threatening effects which include Myocarditis, which are responsible for the discontinuation of Dehydroemetine (HCl) therapy. The signs and symptoms that are produced after the acute over dosage of Dehydroemetine (HCl) include Myocardial toxicity. The symptomatic adverse reactions produced by Dehydroemetine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Local pain, Giddiness, ECG changes, Pain at injection site.
Warnings
Use with caution in congestive heart failure, recent myocardial infarction, cardiomyopathy, or primary muscular or neurological disorders. The safety of dehydroemetine in pregnancy has not been determined.
High Risk Groups
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
1.285 mg/kg (1.3 (1.285)) 24 hourly IM — For 10 Days
Child Dosage
1 mg/kg (1 (1)) 12 hourly Intra Muscular — For not more than 10 Days
Neonatal Dosage
0.5 to 0.7 mg/kg (0.6 (0.6)) 12 hourly Intra Muscular — For not more than 10 Days
Drug Interactions
No data regarding the interactions of Dehydroemetine (HCl) was found.
Storage
No storage information is recorded for this medicine yet.
Available Brands in Pakistan
No brands are recorded for this generic.