DENOSUMAB
Generic medicine reference
Overview
Denosumab is a human monoclonal antibody that works by inhibiting RANKL (receptor activator of nuclear factor kappa-B ligand), a protein essential for osteoclasts' formation, function, and survival.
By inhibiting RANKL, denosumab decreases bone resorption and increases bone mass and strength.
In the United States, denosumab is marketed under the following brand names and biosimilars:
Prolia (biosimilars Bildyos, Boncresa, Bosaya, Conexxence , Enoby, Jubbonti, Ospomyv , Osvyrti, Stoboclo, and Ponlimsi) for osteoporosis-related conditions Xgeva (biosimilars Aukelso, Bilprevda, Bomyntra , Jubereq, Osenvelt , Oziltus, Wyost , Xbryk , and Xtrenbo) for the prevention of skeletal-related events due to certain cancers, or as a second-line treatment for hypercalcemia of malignancy.
Indications
Denosumab is a human monoclonal antibody that works by inhibiting RANKL (receptor activator of nuclear factor kappa-B ligand), a protein essential for osteoclasts' formation, function, and survival.
By inhibiting RANKL, denosumab decreases bone resorption and increases bone mass and strength.
In the United States, denosumab is marketed under the following brand names and biosimilars:
Prolia (biosimilars Bildyos, Boncresa, Bosaya, Conexxence , Enoby, Jubbonti, Ospomyv , Osvyrti, Stoboclo, and Ponlimsi) for osteoporosis-related conditions Xgeva (biosimilars Aukelso, Bilprevda, Bomyntra , Jubereq, Osenvelt , Oziltus, Wyost , Xbryk , and Xtrenbo) for the prevention of skeletal-related events due to certain cancers, or as a second-line treatment for hypercalcemia of malignancy.
Contraindications
DENOSUMAB is contraindicated in conditions like Hypocalcaemia,Hypersensitivity reactions.
Side Effects
Back pain Pain in extremities Musculoskeletal pain Hypercholesterolemia Cystitis.
Warnings
Prolia, Xgeva, and their biosimilars carry a boxed warning for life-threatening severe hypocalcemia (very low calcium levels) in patients with advanced chronic kidney disease (CKD), particularly those on dialysis.
The risk is even greater in those patients with CKD who also have a condition known as mineral and bone disorder (CKD-MBD). Your healthcare provider will evaluate you for CKD-MBD before starting treatment, and monitor you throughout.
High Risk Groups
Prolia, Xgeva, and their biosimilars carry a boxed warning for life-threatening severe hypocalcemia (very low calcium levels) in patients with advanced chronic kidney disease (CKD), particularly those on dialysis.
The risk is even greater in those patients with CKD who also have a condition known as mineral and bone disorder (CKD-MBD). Your healthcare provider will evaluate you for CKD-MBD before starting treatment, and monitor you throughout.
Adult Dosage
60 mg (60 (60)) As recommended. S/C — given every 6 months
Scraped Dose — Standard Dosage : 60 mg administered as a subcutaneous injection once every 6 months.
Administration : Given by a healthcare professional in the upper arm, upper thigh, or abdomen.
Child Dosage
( ) —
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Limited drug interactions due to the monoclonal antibody nature of denosumab No formal drug interaction studies have been conducted Caution with immunosuppressants due to the potential increased risk of infection.
Storage
inj
Available Brands in Pakistan
No brands are recorded for this generic.
For educational purposes only. Check current guidelines and consult a qualified healthcare professional before making clinical decisions.