Desipramine (HCl)

Desipramine (HCl) is a tricyclic antidepressant. Desipramine (HCl) is the monomethyl derivative of imipramine. Desipramine (HCl) is less sedating than its parent compound. Two to three weeks are required to obtain the full effects of the drug. It may also be used to treat nerve pain, insomnia and bed-wetting in children.

Desipramine (HCl) is primarily indicated in conditions like Cocaine addiction, Depression prophylaxis, Depression, Enuresis.

Desipramine (HCl) is contraindicated in conditions like Cardiac arrhythmia, Mania, Myocardial infarction, Heart block, Hepatic disease Narrow-angle glaucoma, Urinary retention.

The severe or irreversible adverse effects of Desipramine (HCl), which give rise to further complications include Hepatitis, Agranulocytosis.The signs and symptoms that are produced after the acute overdosage of Desipramine (HCl) include Hypotension, Coma, Epileptic seizures, Respiratory depression, Tremor, Ventricular arrhythmias, Delayed cardiac conduction.The symptomatic adverse reactions produced by Desipramine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Nausea, Anxiety, Palpitation, Abdominal pain, Sleep disturbances, Dry mouth, Blurred vision, Confusion, Pruritus, Sedation, Photosensitivity, Weight gain, Tremor, Postural hypotension, Mydriasis, Allergic skin reactions, Vasculitis, Xerostomia, Erectile impotence.

Desipramine should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity, because it may produce allergic reaction (including bronchial asthma). Monitor ECG before initiating large doses of tetracyclines. Avoid concurrent administration with electric shock therapy because may increase the hazards of therapy. Perform periodic leukocytes (white blood cells) counts and liver function tests. Photosensitization may occur so caution patients to take protective measures, sunscreens etc, against exposure to UV light or sun light.

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

0.357 to 0.952 mg/kg (0.65 (0.6545)) 8 hourly PO — -

( ) — Not recommended in this age group

( ) — Not recommended in this age group

Desipramine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholBethanidine (Sulphate)ChloroquineClonidine (HCl)Clonidine (HCl)Debrisoquine (Sulphate)GuanethidineIndacaterolprolong QTc intervalmonitor closelyLithiumLoprazolamTheoretical potential for LOPRAZOLAM increasing the SEDATIVE effect of DESIPRAMINE HYDROCHLORIDE. ModerateMay need to avoid combinationMethyldopaMethylphenidate (HCl)Mibefradil (Di HCl)NabiloneConcurrent use may increase the efficacy of nabilone.Concurrent use should be avoided, or you may need dosage adjustments or special tests during treatment.Propafenone (HCl)Riboflavin (Vitamin B2)Tricyclic antidepressants may reduce levels of riboflavin in the body. In addition to raising levels of the vitamin in the body, taking riboflavin may also improve the effects of these antidepressantsRitonavirVORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation Vortioxetineincreases the level of vortioxetinemonitor closely, use alternative These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.