Dextropropoxyphene

Dextropropoxyphene is a weak narcotic analgesic (reliefs the pain with unconsciousness) and used in the management of moderate pain. Commonly Dextropropoxyphene is given in combination with paracetamol.

Dextropropoxyphene is primarily indicated in conditions like Mild to moderate pain, Opioid addiction.

Dextropropoxyphene is contraindicated in conditions like Psychosis,Hypersensitivity.

The severe or irreversible adverse effects of Dextropropoxyphene, which give rise to further complications include Sinus tachycardia, Hypotension, Orthostatic hypotension, Seizures, Dependence, Cholestasis, Psychosis, Sinus bradycardia, Syncope, Decreased libido, Biliary obstruction. Dextropropoxyphene produces potentially life-threatening effects which include Convulsions. which are responsible for the discontinuation of Dextropropoxyphene therapy. The signs and symptoms that are produced after the acute over dosage of Dextropropoxyphene include Hypotension, Cardiac arrhythmias, Pulmonary edema, Convulsions, Coma, Drowsiness, Respiratory depression, Ataxia, Miosis, Circulatory collapse. The symptomatic adverse reactions produced by Dextropropoxyphene are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Nausea, Vomiting, Anorexia, Restlessness, Palpitation, Constipation, Abdominal pain, Skin rashes, Blurred vision, Confusion, Pruritus, Jaundice, Sedation, Malaise, Diaphoresis, Flushing, Elevation of liver enzymes, Dysphoria, Vision disturbances, Hyponatremia, Urinary Retention.

Dextropropexyphene should be used with caution in patients with respiratory depression, alcoholism, convulsive disorder, head injuries, hypothyroidism, asthma, impaired kidney or liver function. It should be used with great care in infants or neonates. Patient should observe caution while driving or performing tasks requiring alertness, because it may produce drowsiness.

Drug should not be given to Pediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

65 mg (65 (65)) 4 hourly PO — Maximum dose 390 mg/day. Frequency may be increased to 8 times if needed.

( ) — Not recommended in this age group

( ) — Not recommended in this age group

Dextropropoxyphene is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCarbamazepineEffects of Carbamazepine enhanced by Dextropropoxyphene.MajorFosphenytoinPhenobarbitonePhenytoin (Na)RitonavirWarfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Tab Store in a well closed container, Below 25°C.