Diamorphine (HCl)

Diamorphine (HCl) is a narcotic analgesic (reliefes the painn with unconsciousness). It relieves moderate to severe pain. It produces feeling of well being.

Diamorphine (HCl) is primarily indicated in conditions like Chronic pain, Cough, Opioid agonist dependence, Severe acute pain.

Diamorphine (HCl) is contraindicated in conditions like Respiratory disease, Biliary colic, Raised intracranial pressure, Head injury.

The severe or irreversible adverse effects of Diamorphine (HCl), which give rise to further complications include Nephrotic syndrome, Pulmonary edema, Thrombocytopenic purpura, Renal amyloidosis, Rhabdomyolysis, Reduced GFR (glomerular filtration rate), Decrease in sexual desire. The signs and symptoms that are produced after the acute over dosage of Diamorphine (HCl) include Nausea, Vomiting, Pulmonary edema, ECG alterations, Confusion, Respiratory depression, Hypothermia, Miosis, Dysphoria, Sedation, Sinus tachycardia, Rhabdomyolysis. The symptomatic adverse reactions produced by Diamorphine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Constipation, Dry mouth, Pruritus, Sedation, Sweating, Miosis, Respiratory depression, Euphoria, Mental clouding, Calmness, Hypothermia, Hypertension, Dependence, Dry mouth.

The long term administration of diamorphine will result in physical dependence and therefore an obstinence syndrome will occur if diamorphine therapy is abruptly discontinued. Therefore gradually reduces the dosage regimen to prevent the obstinence syndrome. The dose and dosing interval of diamorphine must be titrated against the individual patient reports of their pain.

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

0.071 mg/kg (0.071 (0.071)) 4 hourly IV — - 0.071 to 0.143 mg/kg (0.11 (0.107)) 4 hourly IM — - 0.071 to 0.143 mg/kg (0.11 (0.107)) 4 hourly SC — -

0.05 to 0.1 mg/kg (0.075 (0.075)) 4 hourly Intra Muscular — - 0.05 to 0.1 mg/kg (0.075 (0.075)) 4 hourly Subcutaneous — - 100 to 200 mg/kg (150 (150)) 4 hourly PO — 100 to 75 ug/kg (88 (87.5)) 4 hourly IV infusion — 1 to 12 year 12.5 to 25 ug/kg /hr (19 (18.75)) As recommended. IV inj — 1 month to 12 year

0.05 to 0.1 mg/kg (0.075 (0.075)) 4 hourly Intra Muscular — - 0.05 to 0.1 mg/kg (0.075 (0.075)) 4 hourly Subcutaneous — -

No data regarding the interactions of Diamorphine (HCl) was found.

Inj Store Below 30°C. Protect from Sunlight.