Didanosine

Didanosine is used in combination with other medicines for the treatment of human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Didanosine will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay the development of problems usually related to AIDS or HIV disease. Didanosine will not keep you from spreading HIV to other people. People who receive this medicine may continue to have the problems usually related to AIDS or HIV disease. This medicine is available only with your doctor's prescription. The buffered tablets that are to be chewed, crushed or mixed with water are no longer available in the United States. This product was voluntarily discontinued, and it was not due to safety concerns. Didanosine delayed-release capsules (Videx® EC) and pediatric powder for oral solution are still available.

Didanosine is used in combination with other medicines for the treatment of human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Didanosine will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay the development of problems usually related to AIDS or HIV disease. Didanosine will not keep you from spreading HIV to other people. People who receive this medicine may continue to have the problems usually related to AIDS or HIV disease. This medicine is available only with your doctor's prescription. The buffered tablets that are to be chewed, crushed or mixed with water are no longer available in the United States. This product was voluntarily discontinued, and it was not due to safety concerns. Didanosine delayed-release capsules (Videx® EC) and pediatric powder for oral solution are still available.

Didanosine is contraindicated in conditions like Pancreatitis, Renal failure, Peripheral neuropathy, Liver diseases, Hypersensitivity.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common Nausea stomach pain tingling, burning, numbness, and pain in the hands or feet vomiting Rare Chills fever itching, skin rash seizures sore throat swelling of the feet or lower legs unusual bleeding and bruising unusual tiredness and weakness yellow skin and eyes Incidence not known Anxiety black, tarry stools bleeding gums blindness bloating blood in the urine or stools blue-yellow color blindness blurred vision change in the color of the eye chest pain clay colored stools cold sweats confusion constipation cool, pale skin cough dark urine decreased appetite decreased vision depression diarrhea difficulty with moving difficulty with swallowing dizziness dry eyes or mouth eye pain fast heartbeat fast, shallow breathing flushed, dry skin fruit-like breath odor general feeling of discomfort headache hives increased hunger increased thirst increased urination indigestion joint pain light-colored stools loss of appetite loss of consciousness muscle aching, cramping, or pain nightmares painful or difficult urination pains in the stomach, side, or abdomen, possibly radiating to the back pinpoint red spots on the skin puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue right upper abdominal or stomach pain and fullness shakiness sleepiness slurred speech sores, ulcers, or white spots on the lips or in the mouth stomach ache or discomfort sweating swollen glands or joints tightness in the chest troubled breathing with exertion unexplained weight loss unsteadiness or awkwardness weakness in the arms, hands, legs, or feet Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Difficulty with sleeping irritability restlessness Incidence not known Belching excess air or gas in the stomach or bowels feeling of fullness hair loss or thinning of the hair heartburn indigestion lack or loss of strength passing gas Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

It should be used with caution in patient with impaired renal or hepatic function. Regular checks of liver function are recommended. If liver function deteriorates during treatment then Didanosine should be withdrawn. Children and adults should be monitored for retinal lesions and Didanosine should be withdrawn if they occur.

Drug should not be given to Pregnant Mothers, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

125 mg (120 (125)) 12 hourly PO — For at less than 60 kg. 200 mg (200 (200)) 24 hourly PO — For at least 60 kg.

180 mg/m2 (180 (180)) As recommended. combination with zidovudine in 1-2 divided dose. older than 6th year of age. As single dose or indiv — 240 mg/m2 (240 (240)) 24 hourly Combination with zidovudine in 1-2 divided doses. —

No neonatal dosage information is recorded for this medicine yet.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Allopurinol Oxypurinol Ribavirin Stavudine Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Atazanavir Cabotegravir Darunavir Hydroxyurea Orlistat Tacrolimus Tenofovir Disoproxil Fumarate Zalcitabine Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Atevirdine Ciprofloxacin Delavirdine Enoxacin Ganciclovir Indinavir Itraconazole Ketoconazole Lomefloxacin Methadone Metoclopramide Moxifloxacin Nelfinavir Nirmatrelvir Norfloxacin Ofloxacin Ranitidine Rifabutin Ritonavir Sulfamethoxazole Trimethoprim Trovafloxacin Mesylate Valganciclovir

Oral Soln (reconstituted) Store at room temperature. Use within 4 hrs if kept at room temperature. Pediatric Oral Soln Store in refrigerator. Use within 30 days if kept at room temperature. Powder for Oral Soln Store at room temperature. Tab Store in a well closed container, at room temperature. Protect from Moisture.