Diethylcarbamazine (Citrate)
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Diethylcarbamazine (Citrate) is anthelmintic agent. Diethylcarbamazine (Citrate) is used to treat filariasis (nematode infection).
Indications
Diethylcarbamazine (Citrate) is primarily indicated in conditions like Filarial infection, Lymphatic filariasis, Onchocerciasis.
Contraindications
Diethylcarbamazine (Citrate) is contraindicated in conditions like Hypersensitivity to murine proteins.
Side Effects
Diethylcarbamazine (Citrate) produces potentially life-threatening effects which include Conjunctivitis, Visual field loss, Encephalitis, Retinal hemorrhage, Mazzotti Reaction, Iridocyclitis. which are responsible for the discontinuation of Diethylcarbamazine (Citrate) therapy. The signs and symptoms that are produced after the acute over dosage of Diethylcarbamazine (Citrate) include Nausea, Vomiting, Drowsiness, Dizziness. The symptomatic adverse reactions produced by Diethylcarbamazine (Citrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Nausea, Fever, Chills.
Warnings
Diethylcarbamazine should be used with caution in patients with renal impairment. Avoid use in infants, pregnant women, elderly or debiliated, especially in those with cardiac or renal disease. and in hyper sensitive patients.
High Risk Groups
Drug should not be given to Pediatrics, Pregnant Mothers, patients suffering from Liver Malfunction, Geriatrics, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
0.357 to 2.5 mg/kg (1.4 (1.4285)) 24 hourly PO — Initial
1.428 mg/kg (1.4 (1.428)) 8 hourly PO — Maintenance, Gradually increase as Required
Child Dosage
1 mg/kg (1 (1)) 8 hourly Oral — Initially for 3 days
2 mg/kg (2 (2)) 8 hourly Oral — Maintenance for 21 Days
Neonatal Dosage
1 mg/kg (1 (1)) 8 hourly Oral — Initially for 3 days
2 mg/kg (2 (2)) 8 hourly Oral — Maintenance for 21 Days
Drug Interactions
Diethylcarbamazine (Citrate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAcetazolamide (Na)Acetazolamide reduce urinary excretion and enhance pharmacological effect These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Tab Store in a well closed container, at room temperature.
Available Brands in Pakistan
No brands are recorded for this generic.