Dinoprost

Dinoprost is a natural oxytocic prostaglandin. Dinoprost is a synthetic derivative of itone in which the O atom in 9-position of the latter is reduced to OH. Dinoprost is effective as an abortifacient i.e., causing abortion.

Dinoprost is primarily indicated in conditions like Abortion, Haemorrhage, Hydatidiform mole, Labor induction.

Dinoprost is contraindicated in conditions like Asthma, Glaucoma, Pelvic infections.

The severe or irreversible adverse effects of Dinoprost, which give rise to further complications include Intravascular coagulation. Dinoprost produces potentially life-threatening effects which include Cardiogenic collapse, which are responsible for the discontinuation of Dinoprost therapy. The signs and symptoms that are produced after the acute over dosage of Dinoprost include Collapse, Severe GI symptoms. The symptomatic adverse reactions produced by Dinoprost are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Flushing, Pyrexia, Bronchospasm, Shivering, Wheezing, bronchoconstriction.

User Safety: Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water. Contact Information: To report adverse reactions call Bimeda, Inc. at 1-888-524-6332. Residue Warnings: No milk discard or preslaughter drug withdrawal period is required for labeled uses in cattle. No preslaughter drug withdrawal period is required for labeled uses in swine. Use of this product in excess of the approved dose may result in drug residues. Do not use in horses intended for human consumption. Animal Safety Warnings: Severe localized clostridial infections associated with injection of dinoprost tromethamine injection have been reported. In rare instances, such infections have resulted in death. Aggressive antibiotic therapy should be employed at the first sign of infection at the injection site whether localized or diffuse. Do not administer intravenously (IV) as this route may potentiate adverse reactions. Non-steroidal anti-inflammatory drugs may inhibit prostaglandin synthesis; therefore this class of drugs should not be administered concurrently. Do not administer to pregnant cattle, unless abortion is desired. Cattle administered a progestin would be expected to have a reduced response to ProstaMate. Do not administer to sows and/or gilts prior to 3 days of normal predicted farrowing as an increased number of stillbirths and postnatal mortality may result. In mares, ProstaMate is ineffective when administered prior to day-5 after ovulation. Mare pregnancy status should be determined prior to treatment since dinoprost tromethamine injection has been reported to induce abortion and parturition when sufficient doses were administered. Mares should not be treated if they suffer from either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system, or reproductive tract.

User Safety: Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water. Contact Information: To report adverse reactions call Bimeda, Inc. at 1-888-524-6332. Residue Warnings: No milk discard or preslaughter drug withdrawal period is required for labeled uses in cattle. No preslaughter drug withdrawal period is required for labeled uses in swine. Use of this product in excess of the approved dose may result in drug residues. Do not use in horses intended for human consumption. Animal Safety Warnings: Severe localized clostridial infections associated with injection of dinoprost tromethamine injection have been reported. In rare instances, such infections have resulted in death. Aggressive antibiotic therapy should be employed at the first sign of infection at the injection site whether localized or diffuse. Do not administer intravenously (IV) as this route may potentiate adverse reactions. Non-steroidal anti-inflammatory drugs may inhibit prostaglandin synthesis; therefore this class of drugs should not be administered concurrently. Do not administer to pregnant cattle, unless abortion is desired. Cattle administered a progestin would be expected to have a reduced response to ProstaMate. Do not administer to sows and/or gilts prior to 3 days of normal predicted farrowing as an increased number of stillbirths and postnatal mortality may result. In mares, ProstaMate is ineffective when administered prior to day-5 after ovulation. Mare pregnancy status should be determined prior to treatment since dinoprost tromethamine injection has been reported to induce abortion and parturition when sufficient doses were administered. Mares should not be treated if they suffer from either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system, or reproductive tract.

0.029 ug/kg.min (0.029 (0.029)) As recommended. IV Inf — As Required 3 mg (3 (3)) As recommended. Intra Vaginal — A 2nd tab. may be inserted after 6-8 hrs. If labour is not established. Scraped Dose — As with any multi-dose vial, practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections. Adequately clean and disinfect the vial stopper prior to entry with a sterile needle and syringe. Use only sterile needles, and use each needle only once. Use within 3 months of first puncture and puncture a maximum of 20 times with a needle or 5 times with a dosage delivery device. When using a draw-off spike or needle with bore diameter larger than 4.90 mm, discard any product remaining in the vial immediately after use. Cattle: 1. For Estrus Synchronization in Beef Cows, Beef Heifers and Replacement Dairy Heifers. ProstaMate is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 5 mL ProstaMate (25 mg dinoprost) intramuscularly either once or twice at a 10 to 12 day interval. With the single injection, cattle should be bred at the usual time relative to estrus. With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of ProstaMate. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present. Cattle that do not become pregnant to breeding at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days. 2. For Unobserved (Silent) Estrus in Lactating Dairy Cows with a Corpus Luteum. Inject a dose of 5 mL ProstaMate (25 mg dinoprost) intramuscularly. Breed cows as they are detected in estrus. If estrus has not been observed by 80 hours after injection, breed at 80 hours. If the cow returns to estrus, breed at the usual time relative to estrus. 3. For Treatment of Pyometra (chronic endometritis) in Cattle . Inject a dose of 5 mL ProstaMate (25 mg dinoprost) intramuscularly. 4. For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers . ProstaMate is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Inject a dose of 25 mg dinoprost (5 mL) intramuscularly. Cattle that abort will abort within 35 days of injection. 5. For use with gonadorelin injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: Administer 2 to 4 mL gonadorelin injection (100-200 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework: • Administer the first dose of gonadorelin injection (2-4 mL) at Day 0. • Administer ProstaMate (25 mg dinoprost, as dinoprost tromethamine) by intramuscular injection 6-8 days after the first dose of gonadorelin injection. • Administer a second dose of gonadorelin injection (2-4 mL) 30 to 72 hours after the ProstaMate injection. • Perform FTAI 0 to 24 hours after the second dose of gonadorelin injection, or inseminate cows on detected estrus using standard herd practices. Below are three examples of treatment regimens for FTAI that fit within the dosage regimen framework described immediately above: 6. For use with EAZI-BREED™ CIDR ® (progesterone intravaginal insert) Cattle Insert for Synchronization of Estrus in Lactating Dairy Cows: • Administer one EAZI-BREED™ CIDR ® Cattle Insert per animal and remove 7 days later (for example if administered on a Monday remove the following Monday). • Administer 5 mL ProstaMate at the time of removal of the EAZI-BREED™ CIDR ® Cattle Insert. • Observe animals for signs of estrus on Days 2 to 5 after removal of the EAZI-BREED™ CIDR ® Cattle Insert and inseminate animals found in estrus following normal herd practices. 7. For use with EAZI-BREED™ CIDR ® (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers: • Administer one EAZI-BREED™ CIDR ® Cattle Insert per animal for 7 days (for example, if administered on a Monday remove on the following Monday). • Inject 5 mL ProstaMate (equivalent to 5 mg/mL dinoprost) 1 day prior to EAZI-BREED™ CIDR ® Cattle Insert removal, on Day 6 of the 7 day administration period. • Observe animals for signs of estrus on Days 1 to 3 after removal of the EAZI-BREED™ CIDR ® Cattle Insert and inseminate animals about 12 hours after onset of estrus. Swine: For Parturition Induction in Swine: For intramuscular use for parturition induction in swine. ProstaMate is indicated for parturition induction in swine when injected within 3 days of normal predicted farrowing. The response to treatment varies by individual animals with a mean interval from administration of 2 mL ProstaMate (10 mg dinoprost) to parturition of approximately 30 hours. This can be employed to control the time of arrowing in sows and gilts in late gestation. Management Considerations: Several factors must be considered for the successful use of ProstaMate for parturition induction in swine. The product must be administered at a relatively specific time (treatment earlier than 3 days prior to normal predicted farrowing may result in increased piglet mortality). It is important that adequate records be maintained on (1) the average length of gestation period for the animals on a specific location, and (2) the breeding and projected farrowing dates for each animal. This information is essential to determine the appropriate time for administration of ProstaMate. Mares: ProstaMate is indicated for its luteolytic effect in mares. Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2 mL ProstaMate. This luteolytic effect can be utilized to control the timing of estrus in estrous cycling and clinically anestrous mares that have a corpus luteum in the following circumstances: 1. Controlling Time of Estrus of Estrous Cycling Mares: Mares treated with ProstaMate during diestrus (4 or more days after ovulation) will return to estrus within 2 to 4 days in most cases and ovulate 8 to 12 days after treatment. This procedure may be utilized as an aid to scheduling the use of stallions. 2. Difficult-to-Breed Mares: In extended diestrus there is failure to exhibit regular estrous cycles which is different from true anestrus. Many mares described as anestrus during the breeding season have serum progesterone levels consistent with the presence of a functional corpus luteum. A proportion of “barren”, maiden, and lactating mares do not exhibit regular estrous cycles and may be in extended diestrus. Following abortion, early fetal death and resorption, or as a result of “pseudopregnancy”, there may be serum progesterone levels consistent with a functional corpus luteum. Treatment of such mares with ProstaMate usually results in regression of the corpus luteum followed by estrus and/or ovulation. Treatment of “anestrous” mares which abort subsequent to 36 days of pregnancy may not result in return to estrus due to presence of functional endometrial cups.

Not applicable in this age group ( ) —

No neonatal dosage information is recorded for this medicine yet.

No data regarding the interactions of Dinoprost was found.

Inj Store Below 40°C.