Diphenoxylate (HCl)
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Diphenoxylate (HCl) is a synthetic derivative of pethidine with little or no analgesic activity. It reduces the gut motility and is used to treat diarrhea.
Indications
Diphenoxylate (HCl) is primarily indicated in conditions like Diarrhoea.
Contraindications
Diphenoxylate (HCl) is contraindicated in conditions like Ulcerative colitis, Pseudomembranous colitis, Intestinal obstruction, Colitis, Crohn's disease, Hepatic dysfunction.
Side Effects
The severe or irreversible adverse effects of Diphenoxylate (HCl), which give rise to further complications include Pancreatitis, Paralytic ileus, Hyperglycemia, Hemorrhagic colitis, Hyperglycemia, Toxic megacolon. Diphenoxylate (HCl) produces potentially life-threatening effects which include Anaphylactoid reactions, Pseudomembranous colitis, Portosystemic encephalopathy, Inflammatory bowel disease, which are responsible for the discontinuation of Diphenoxylate (HCl) therapy. The signs and symptoms that are produced after the acute over dosage of Diphenoxylate (HCl) include Flushing, Tachycardia, Coma, Hyperthermia, Urinary retention, Respiratory depression, Nystagmus, Lethargy, Pinpoint pupils, Dry mucous membrane, Hypotonic reflexes, Narcosis. The symptomatic adverse reactions produced by Diphenoxylate (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Abdominal distension, Dizziness, Headache, Drowsiness, Nausea, Vomiting, Anorexia, Restlessness, Confusion, Urticaria, Pruritus, Lethargy, Sedation, Hallucination, Malaise, Depression, Somnolence, Euphoria, Hypersensitivity reactions, Paralytic ileus, Gum swelling, Angioedema, Toxic megacolon.
Warnings
Patient should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. Diphenoxylate should be used with caution in patients with impaired liver function. Avoid use in patients with jaundice. It should be used with caution in young children, because of greater variability of response in this age group. It is not recommended for use in infant. Patients with inflammatory bowel disease should be carefully observed if receiving diphenoxylate for sign of toxic megacolon.
High Risk Groups
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
5 mg (5 (5)) 8 hourly PO — Initial
Child Dosage
( ) — Not recommended in this age group
Neonatal Dosage
( ) — Not recommended in this age group
Drug Interactions
No data regarding the interactions of Diphenoxylate (HCl) was found.
Storage
Liq Store Below 40°C. Do not Freeze. Protect from Sunlight and Moisture. Tab Store Below 40°C. Protect from Sunlight and Moisture.
Available Brands in Pakistan
No active brands are currently recorded for this generic.
2 records are present but flagged "Unverified / Legacy" and excluded.