Distigmine (Br)
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Distigmine (Br) is a parasympathomimetic, used in the prevention and treatment of post-operative gastro-intestinal atony and in post-operative urinary retention. Antibiotic (aminoglycoside, tetracycline, polymycin)
Indications
Distigmine (Br) is primarily indicated in conditions like Intestinal atony, Neurogenic bladder, Postoperative ileus, Postoperative urinary retention, Prophylaxis of NSAID-associated gastric or duodenal ulcer, and can also be given in adjunctive therapy as an alternative drug of choice in Extravasation/haematoma, Myasthenia gravis.
Contraindications
Distigmine (Br) is contraindicated in conditions like Circulatory insufficiency, GI obstruction, Urinary outflow obstruction.
Side Effects
The severe or irreversible adverse effects of Distigmine (Br), which give rise to further complications include Bronchospasm, AV-block, Sinus bradycardia, Dyspnea, Cholinergic crises. Distigmine (Br) produces potentially life-threatening effects which include Coma, Bradycardia, Convulsions, Neuromuscular blockage, Hypotension, Hypoxemia, Paralysis, Bronchoconstriction, Severe muscle weakness, which are responsible for the discontinuation of Distigmine (Br) therapy. The signs and symptoms that are produced after the acute over dosage of Distigmine (Br) include Nausea, Sweating, Increased peristalsis, Pallor, Retching, Spasticity, Paralysis. The symptomatic adverse reactions produced by Distigmine (Br) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Abdominal cramps, Sweating, Miosis, Salivation, Urinary urgency.
Warnings
Distigmine should be used with caution in patients with asthma, seizure disorder, epilepsy, heart disease such as hypertension, bradycardia, recent myocardial infraction, thyroid disorders, intestinal disorders, ulcers, urinary problems or if have any allergy especially to bromides. Large dose by mouth should be avoided in condition where there may be increase absorption from the gastrointestinal tract. It should be used only if clearly needed during pregnancy.
High Risk Groups
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
0.007 mg/kg (0.007 (0.007)) 24 hourly IM —
0.071 to 0.142 mg/kg (0.11 (0.1065)) 12 hourly PO — As Required
Child Dosage
10 mg (10 (10)) As recommended. daily —
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
No data regarding the interactions of Distigmine (Br) was found.
Storage
Tab Store Below 25°C. Protect from Moisture.
Available Brands in Pakistan
No brands are recorded for this generic.