Dobutamine (HCl)

Dobutamine is a synthetic, direct acting catecholamine that is a ß1 receptor agonist. Dobutamine (HCl) is available as racemic mixture. Chemically it resembles dopamine. It provides additional pumping strength by stimulating the heart muscle and effective to treat low output acute heart failure

Dobutamine (HCl) is primarily indicated in conditions like Acid reflux disease (long-term management), Cardiac surgery, Cardiogenic shock, Cardiomyopathies, Heart failure, Hypotensive shock, Inotropic support in infarction, Septic shock, and can also be given in adjunctive therapy as an alternative drug of choice in Positive end expiratory pressure ventilation.

Dobutamine (HCl) is contraindicated in conditions like Obstructive cardiomyopathy, Constrictive pericarditis, Low cardiac filling pressure, Cardiac tamponade, Ventricular arrhythmias.

The severe or irreversible adverse effects of Dobutamine (HCl), which give rise to further complications include Tissue necrosis.Dobutamine (HCl) produces potentially life-threatening effects which include Myocardial Ischemia, Tachycardia, Cardiac arrhythmias, Hypertension, Hypotension, Myocardial ischemia, Extravasation. which are responsible for the discontinuation of Dobutamine (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Dobutamine (HCl) include Hypertension, Peripheral vasoconstriction, Myocardial ischemia, Arrhythmias.The symptomatic adverse reactions produced by Dobutamine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Nausea, Vomiting, Palpitation, Non-specific chest pain, Breathlessness, Bronchospasm, Chest pain, Paresthesias, Reaction at injection site.

Correct hypovolemia with suitable volume expender before starting treatment with dobutamine in hypovolemic patients. Continuously monitor ECG, blood pressure and cardiac output. It should be used with extreme caution in patient with acute myocardial infarction. It is classified as pregnancy category C and should be avoided during pregnancy unless the potential benefit outweighs the isk to the fetus. Avoid in arrythmias, severe hypotension.

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

175 to 2800 ug/min (1500 (1487.5)) As recommended. IV Inf — As Required

2.15 to 20 mcg/kg/min (11 (11.075)) As recommended. as required — 5 mcg/kg/min (5 (5)) As recommended. as reqiured. —

2.5 to 15 ug/kg.min (8.8 (8.75)) As recommended. Infusion — As required

Dobutamine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDopamine (HCl)HalothaneMilrinone (Lactate)Phentolamine (Mesylate)PrazosinSodium Nitroprusside These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Inj (reconstituted soln) Store at room temperature. Use within 24 hrs if kept at room temperature.