Donepezil (HCl)

Donepezil (HCl) is a piperidine derivative, is a reversible and specific inhibitor of acetylcholinesterase. Donepezil (HCl) is highly selective for the CNS and is used in the symptomatic treatment of mild to moderate dementia in Alzheimer`s disease.

Donepezil (HCl) is primarily indicated in conditions like Alzheimer's disease, Induction of general anaesthesia, and can also be given in adjunctive therapy as an alternative drug of choice in Sclerosis, Vascular disease.

Donepezil (HCl) is contraindicated in conditions like Pregnancy, Breast feeding.

The severe or irreversible adverse effects of Donepezil (HCl), which give rise to further complications include Ataxia, Cataract, Pruritus, Intraperitoneal hemorrhage, Cataract, Supraventricular tachycardia, Skin ulceration, Hirsutism, Conjunctival Hemorrhage, Blepharitis. Donepezil (HCl) produces potentially life-threatening effects which include Thrombocytopenia, Neuroleptic Malignant Syndrome, Neuroleptic malignant syndrome, Pneumonia. which are responsible for the discontinuation of Donepezil (HCl) therapy. The symptomatic adverse reactions produced by Donepezil (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Anorexia, Diarrhea, Insomnia, Rashes, Confusion, Pruritus, Hallucination, Psychiatric disturbance, Urinary incontinence, Nausea and vomiting, Muscle cramps, Syncope.

Donepezil (HCl) should be used with caution in patients with sick sinus syndrome or other supraventricular conduction abnormalities; susceptibility to peptic ulcer; asthma, chronic obstructive pulmonary disease; may exacerbate extrapyramidal symptoms; hepatic impairment.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

10 mg (10 (10)) 24 hourly PO — Mild to Moderate Alzheimer''s Type Dementia: Should be taken in the evening. 20 mg (20 (20)) 24 hourly PO — Moderate to severe Alzheimer''''s Type Dementia: Should be taken in the evening.

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Donepezil (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAcepromazine (Maleate)ChlorprothixeneClemastineGlycopyrrolateKetoconazole These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Store at room temperature, Between 15°C-30°C.