Dopexamine (HCl)
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Dopexamine (HCl) is a sympathomimetic, stimulates beta-2 adrenoceptors and peripheral dopamine receptors. It also inhibits neuronal reuptake of noradrenaline. Dopexamine (HCl) is used to provide haemodynamic support that may be required after cardiac surgery or in exacerbation of chronic heart failure. Dopexamine (Dopacard) is a synthetic analog related to dopermine with intrinsic activity at dopamine D1 and D2 receptors as well as at b2 receptors; it may have others effects such as inhibition of catecholamine up take in patients with law cardiac output, dopexamine infusion significantly increase stroke volume with a decrease in systemic vascular resistance.
Indications
Dopexamine (HCl) is primarily indicated in conditions like Cardiac surgery, Chronic heart failure, Heart failure associated with cardiac surgery, Inotropic support and vaso, Sedation of patients receiving intensive care, and can also be given in adjunctive therapy as an alternative drug of choice in Acute exacerbation of chronic heart failure, Sepsis, Shock.
Contraindications
Dopexamine (HCl) is contraindicated in conditions like Hypovolemia, Myocardial infarction, Pheochromocytoma, Thyrotoxicosis, Thrombocytopenia, Left ventricular outflow obstruction.
Side Effects
The signs and symptoms that are produced after the acute overdosage of Dopexamine (HCl) include Hypotension, Nausea, Vomiting, Tachycardia, Ventricular arrhythmias, Tremulousness, Ischemic chest pain. The symptomatic adverse reactions produced by Dopexamine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Dyspnea, Tachycardia, Sweating, Hypotension, Tremor, Thrombocytopenia, Chest pain, Angina, Atrial fibrillation, Supraventricular tachycardia, Decreased sweating, Cardiac failure, Arrhythmia.
Warnings
It should be used with caution in patients with ischemic heart disease or following myocardial infarction. Care is required in presence of hyperglycemia or hypokalemia. Pre-existing hypotension and reduced vascular resistance should be corrected before beginning dopexamine administration. Caution:- Myocardial infraction , recent angina, hypokalemia, hyperglycemia; correct hypovolemia before starting and during treatment monitor blood pressure, pulse, plasma potassium and blood glucose; hyperthyroidism; avoid abrupt withdrawal.
High Risk Groups
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
No adult dosage information is recorded for this medicine yet.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
No data regarding the interactions of Dopexamine (HCl) was found.
Storage
IV Inf Store Below 25°C. Protect from Sunlight.
Available Brands in Pakistan
No brands are recorded for this generic.