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Medicines/Generics/Efavirenz

Efavirenz

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview
Efavirenz is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body. Efavirenz is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Efavirenz is for adults and children who are at least 3 months old and weigh at least 8 pounds. Efavirenz is not a cure for HIV or AIDS. Efavirenz may also be used for purposes not listed in this medication guide.
Indications
Efavirenz is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body. Efavirenz is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Efavirenz is for adults and children who are at least 3 months old and weigh at least 8 pounds. Efavirenz is not a cure for HIV or AIDS. Efavirenz may also be used for purposes not listed in this medication guide.
Contraindications
You should not use efavirenz if you are allergic to it, or if you also take elbasvir and grazoprevir (Zepatier) to treat hepatitis C. Do not take with Atripla (combination efavirenz, emtricitabine , and tenofovir ), unless your doctor tells you to. Tell your doctor if you have ever had: liver disease (including hepatitis B or C); long QT syndrome ; a seizure; mental illness or psychosis; heart disease ; or if you drink large amounts of alcohol or have a history of injection drug use. Do not use efavirenz if you are pregnant. It could harm the unborn baby or cause birth defects. Use 2 forms of birth control , including a barrier form (condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy while you are using efavirenz and for at least 12 weeks after your last dose. Tell your doctor if you become pregnant during treatment. Hormonal contraception ( birth control pills , injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy while you are taking efavirenz. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby. Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
Side Effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat , burning eyes, skin pain, red or purple skin rash with blistering and peeling). Efavirenz may cause serious side effects. Call your doctor at once if you have: a seizure; hallucinations, trouble concentrating, trouble speaking or moving (these symptoms may occur months or years after you start taking efavirenz); nervous system problems --dizziness, drowsiness , confusion, trouble concentrating, strange dreams, insomnia, or problems with speech, balance, or muscle movement; serious psychiatric symptoms --anxiety, paranoia, unusual behavior, feeling sad or hopeless, hallucinations, suicidal thoughts; or liver problems --nausea, stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); Psychiatric symptoms or nervous system problems may happen even months or years after you have been taking efavirenz. Efavirenz affects your immune system, which may cause certain side effects (even weeks or months after you've taken efavirenz). Tell your doctor if you have: signs of a new infection --fever, night sweats, swollen glands, cold sores , cough, wheezing, diarrhea, weight loss ; trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence. Common side effects of efavirenz may include: nausea, vomiting; dizziness, drowsiness, trouble concentrating; rash; headache, tired feeling; sleep problems (insomnia), strange dreams; or changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
You should not use efavirenz if you also take elbasvir and grazoprevir (Zepatier) to treat hepatitis C .
High Risk Groups
You should not use efavirenz if you also take elbasvir and grazoprevir (Zepatier) to treat hepatitis C .
Adult Dosage
600 mg (600 (600)) 24 hourly PO — Scraped Dose — Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Efavirenz must be given in combination with other antiviral medications and it should not be used alone. Your disease may become resistant to efavirenz if you do not take it in combination with other HIV medicines your doctor has prescribed. Take efavirenz on an empty stomach at bedtime. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Swallow the tablet whole and do not crush, chew, or break it. If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce, yogurt, grape jelly, or infant formula (if you are giving the medicine to a baby). Swallow the mixture right away. Do not save it for later use. After taking efavirenz using the sprinkle method, do not eat for the next 2 hours. If you give efavirenz mixed with infant formula to a baby, do not feed more formula for at least 2 hours afterward. Efavirenz doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight. You will need frequent medical tests. Take efavirenz regularly to get the most benefit. Skipping doses may increase the risk of your virus becoming resistant to antiviral medicine. Store at room temperature away from moisture and heat. This medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use efavirenz. Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Efavirenz can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure , depression , mental illness, cancer, malaria, or HIV. Other drugs may affect efavirenz, including prescription and over-the-counter medicines, vitamins, and herbal products . Tell your doctor about all your current medicines and any medicine you start or stop using.
Storage
No storage information is recorded for this medicine yet.

Available Brands in Pakistan

2 active brands listed alphabetically.

EFA

Active

GETZ PHARMA PAKISTAN (PVT) LTD.

DML: EFA

Tabs

EFAVIR

Active

IRZA PHARMA (PVT) LTD.

DML: EFAVIR

Tabs

1 additional record is present but flagged "Unverified / Legacy" and not listed.