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Medicines/Generics/Epirubicin

Epirubicin

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview
Epirubicin is used to treat breast cancer . Epirubicin may also be used for purposes not listed in this medication guide.
Indications
Epirubicin is used to treat breast cancer . Epirubicin may also be used for purposes not listed in this medication guide.
Contraindications
Before you are treated with epirubicin, tell your doctor about all other cancer medications and treatments you have received, including radiation. You should not use this medication if you are allergic to epirubicin or similar medications (such as daunorubicin , doxorubicin , idarubicin , mitoxantrone , or valrubicin ), or if you have: an untreated or uncontrolled infection (including mouth sores); severe liver disease; severe heart problems; or if you have recently had a heart attack. You may not be able to use epirubicin if you have already been treated with a certain amount of other cancer medications. Tell your doctor if you have ever had: heart problems; radiation to your chest area; liver or kidney disease; bone marrow suppression; or chemotherapy with doxorubicin, daunorubicin, epirubicin, idarubicin, or mitoxantrone. Using epirubicin may increase your risk of developing other cancers, such as leukemia. Ask your doctor about this risk. Both men and women using this medicine should use effective birth control to prevent pregnancy. Epirubicin can harm an unborn baby if the mother or father is using this medicine. Epirubicin may cause you to stop having menstrual periods and may also cause premature menopause. Talk with your doctor if you have concerns about these risks. You should not breastfeed while using epirubicin.
Side Effects
Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. Epirubicin can cause dangerous effects on your heart that may not be reversible and could occur months to years after you receive epirubicin. Call your doctor right away if you have symptoms of heart problems : swelling, rapid weight gain, shortness of breath . Also call your doctor at once if you have: fast or slow heartbeats; easy bruising, unusual bleeding, purple or red spots under your skin; unusual tiredness, feeling light-headed or short of breath, cold hands and feet; pain, blistering, redness, bruising, or skin changes where the injection was given; severe vomiting; dehydration symptoms --feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; fluid build-up in or around the lungs --pain when you breathe, feeling short of breath while lying down, wheezing, gasping for breath, cough with foamy mucus, cold and clammy skin, anxiety, rapid heartbeats; signs of tumor cell breakdown --tiredness, weakness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate , tingling in your hands and feet or around your mouth; or signs of infection --fever, chills, flu symptoms, mouth sores, shallow breathing, pale or blue-colored skin. Common side effects of epirubicin may include: nausea, vomiting, diarrhea; temporary hair loss; blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; hot flashes , missed menstrual periods; discoloration of your skin or nails; lack of energy; or red-colored urine for 1 or 2 days after each injection. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
You should not use epirubicin if you have an untreated or uncontrolled infection, severe liver disease , severe heart problems, or if you have recently had a heart attack . You may not be able to use epirubicin if you have already been treated with a certain amount of other cancer medications. Tell your caregivers if you feel any burning, pain, or swelling around the needle when epirubicin is injected. Epirubicin can cause dangerous effects on your heart that may not be reversible and could occur months to years after you receive epirubicin. Call your doctor right away if you have symptoms of heart problems : swelling, rapid weight gain, shortness of breath. Epirubicin affects your immune system. You may get infections more easily, even serious or fatal infections. You will need frequent medical tests and your cancer treatments may be delayed.
High Risk Groups
You should not use epirubicin if you have an untreated or uncontrolled infection, severe liver disease , severe heart problems, or if you have recently had a heart attack . You may not be able to use epirubicin if you have already been treated with a certain amount of other cancer medications. Tell your caregivers if you feel any burning, pain, or swelling around the needle when epirubicin is injected. Epirubicin can cause dangerous effects on your heart that may not be reversible and could occur months to years after you receive epirubicin. Call your doctor right away if you have symptoms of heart problems : swelling, rapid weight gain, shortness of breath. Epirubicin affects your immune system. You may get infections more easily, even serious or fatal infections. You will need frequent medical tests and your cancer treatments may be delayed.
Adult Dosage
60 to 90 mg/ sq.meter (75 (75)) As recommended. IV — Every 3 weeks.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Tell your doctor about all your other medicines, especially: cimetidine (Tagamet); other cancer medicines; or heart or blood pressure medication. This list is not complete. Other drugs may affect epirubicin, including prescription and over-the-counter medicines, vitamins, and herbal products . Not all possible drug interactions are listed here.
Storage
Inj (reconstituted soln) Store in refrigerator. Protect from Sunlight. Use within 24 hrs if kept at room temperature. Vial Store in refrigerator. Protect from Sunlight.