Estrogens Conjugated

Estrogens are important in the development and maintenance of the female urogenital system and secondary sex characteristics. Conjugated estrogen is a mixture of estrogens (hormone), obtained exclusively from natural sources, blended to represent the average composition of material derived from pregnant mare's urine. It contains the sodium salts of water soluble sulfate esters of estrone, Equilin and 17 a-dihydroequilin, together with smaller amounts of 17a estradiol, equilenin, 17ß dihydroequilin, 17ß dihydroequilenin, 17ß estradiol and delta 8, 9 dehydroestrone. The pharmacologic effects of conjugated estrogens are similar to those of endogenous estrogens.

Estrogens Conjugated is primarily indicated in conditions like Estrogen deficiency, Osteoporosis, Urethritis, Vaginitis, and can also be given in adjunctive therapy as an alternative drug of choice in Abnormal uterine bleeding.

Estrogens Conjugated is contraindicated in conditions like Breast cancer, Genital tract bleeding, Thromboembolism, Thrombophlebitis.

The severe or irreversible adverse effects of Estrogens Conjugated, which give rise to further complications include Pancreatitis, Cholestatic jaundice. The symptomatic adverse reactions produced by Estrogens Conjugated are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Alopecia, Abdominal cramps, Rashes, Breakthrough bleeding, Chloasma, Menstrual irregularity, Amenorrhea, Spotting, Bloating, Alopecia.

Estrogen conjugate should be used with caution in patients with medical history, including family medical history, especially breast lumps and cancer, high blood pressure, diabetes, asthma, epilepsy (seizures), migraine headaches, liver, heart or kidney disease, depression, toxemia (high blood pressure during pregnancy), jaundice (yellowing of skin or eyes) during pregnancy, excessive weight gain and fluid retention during the menstrual cycle or if have uterine fibroid tumors. Before having surgery, tell the doctor about the use of the drug. Do not use this medication during pregnancy or lactation. This medication may cause fetal harm. Cigarette smoking can increase the chance of blood clots while using this medication (especially in women pass the age of 35). Higher strengths are more likely to cause melasma (darkening of skin), sunlight may intensify this darkening, so avoid prolonged sun exposure and sunlamps. Consult the doctor regarding use of sunscreens and protective clothing.

Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

0.625 to 1.25 mg (0.94 (0.9375)) 24 hourly PO — As required

1.25 to 2.5 mg (1.9 (1.875)) 3 hourly PO — For palliative treatment of prostatic carcinoma

( ) — Not recommended in this age group

Estrogens Conjugated is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAmobarbitalAmobarbital accelerates the metabolism of estrogen; reduced contraceptive effect.MajorBosentanBosentan possibly causes contraceptive failure of hormonal contraceptives containing estrogens (alternative contraception recommended).MajorCalciferolCapreomycinCapreoycin possibly reduce contraceptive effect of estrogen (risk possibly small).DapsoneBroad spectrum antibacterials (e.g.Dapsone) possibly reduce contraceptive effect of Estrogens.Risk probably small.MajorDiazoxideHypotensive effect of diazoxide antagonised by Estrogens.Gonadorelin (HCl)GriseofulvinInsulin GlulisineEstrogens, corticosteroids, niacin, diuretics, sympathomimetic agents (e.g., epinephrine, albuterol, terbutaline), phenothiazine derivatives, thyroid hormones, progestogens (e.g., in oral contraceptives), protease inhibitors, and atypical antipsychotics may reduce the blood-glucose-lowering effect.Isophane insulinMethylprednisoloneMetyraponeNelfinavirNevirapineNorethisteroneRitonavirSomatropinBecause oral estrogens may reduce the serum IGF-I response to somatropin treatment, girls and women receiving oral estrogen replacement may require greater somatropin dosagesSulphamethizoleConcurrent long-term use of sulfonamides may result in increased incidence of breakthrough bleeding and pregnancySultamicillinReduced oral contraceptive effectiveness in women taking ampicillin, resulting in unplanned pregnancy. patients should be given the option to use an alternate or additional method of contraception while taking ampicillin.Thiamine HCl (Vitamin B1)Estrogens Conjugated may decrease levels of some B vitamins, vitamin C, and zinc in the body.ThymomodulinThymomodulin may show synergism with Estrogens Conjugated. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Inj Store in refrigerator. Inj (reconstituted soln) Use within 60 days if kept at room temperature.